Medical Complications of Psychiatric Treatment

Smith, Felicia A.; Wittmann, Christine; Stern, Theodore A.

doi:10.1016/j.ccc.2008.05.004

Cited by 15 publications

(15 citation statements)

References 65 publications

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“…NMS is an uncommon and lethal neurological disorder [19], attributed to the administration of typical antipsychotics [2, 6, 8, 20, 21] and less commonly to the atypical antipsychotics, like clozapine [5], which has a direct dopaminergic effect but in less proportion than typical antipsychotics especially in D2 receptors. However, clozapine has an effect over serotoninergic pathways that stimulate the 5-HT 1A receptor (5-hydroxytryptamine) causing recirculation of gamma amino butyric acid in the nucleus accumbens leading to the inhibition of the dopaminergic neurons [22], related to the development of the disease.…”

Section: Discussionmentioning

confidence: 99%

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Leonardo

Juliana

Fernando

2017

Case Reports in Emergency Medicine

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The Neuroleptic Malignant Syndrome (NMS) is a medical emergency of infrequent presentation in the emergency department, which is associated with the use of psychiatric drugs, such as typical and atypical antipsychotics. Our case addresses a 55-year-old patient diagnosed with undifferentiated schizophrenia for 10 years, who had been receiving clozapine and clonazepam as part of their treatment. This patient presents the symptoms of Neuroleptic Malignant Syndrome without fever, which improves with treatment especially with the withdrawal of clozapine. In the absence of fever and clinical improvement, the patient is considered to have an atypical presentation of this disease.

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Section: Discussionmentioning

confidence: 99%

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Leonardo

Juliana

Fernando

2017

Case Reports in Emergency Medicine

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“…При длительном применении ТЦА уменьшаются запасы катехоламинов (норадреналина) [52]. Это может приводить к тахикардии, аритмиям, расширению комплекса QRS, удлинению интервала QT, блокаде ветвей пучка Гиса и другим нарушениям проводимости, изменениям зубца Т. При использовании ТЦА в высоких дозах могут возникать желудочковые аритмии и рефрактерная гипотензия [2,3,50,51,53].…”

Section: клиническая диагностика и интраоперационный мониторингunclassified

“…При длительном применении ТЦА уменьшаются запасы катехоламинов (норадреналина) [52]. Это может сопровождаться выраженной артериальной гипотензией [52,65].…”

Section: клиническая диагностика и интраоперационный мониторингunclassified

“…При длительном применении ТЦА уменьшаются запасы катехоламинов (норадреналина) [52]. Это может сопровождаться выраженной артериальной гипотензией [52,65]. Для ее коррекции рекомендуют использовать вазопрессоры прямого действия, например норадреналин [66,67].…”

Section: клиническая диагностика и интраоперационный мониторингunclassified

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Perioperative management of patients with mental diseases

Zabolotskikh¹,

Lebedinsky²,

Myasnikova³

et al. 2018

Anesteziologiya I Reanimatologiya

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Сведения об авторах Заболотских Игорь Борисович-д-р мед. наук, проф., заведующий кафедрой анестезиологии, реаниматологии и трансфузиологии ФПК и ППС ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России, руководитель анестезиологореанимационной службы ГБУЗ «Краевая клиническая больница №2» МЗ КК,

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“…El mecanismo fisiopatológico probablemente se deba al bloqueo de receptores de dopamina a nivel de sistema nervioso central. Esto se ha respaldado en evidencias tales como la asociación con los medicamentos cuyo mecanismo de acción es el bloqueo de receptores dopaminérgicos en el sistema nervioso central, la mayor incidencia entre más fuerte sea la afinidad del fármaco al receptor, y la presencia de síntomas similares al SNM en pacientes con lesiones en (1,2).…”

Section: Introductionunclassified

Neuroleptic malignant-like síndrome

Vera

Denis

Recalde

et al. 2017

Rev. virtual Soc. Parag. Med. Int

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RESUMENEl síndrome neuroléptico maligno like o crisis acinética es una rara y potencialmente letal complicación del abandono de medicación de los pacientes con enfermedad de Parkinson. Se presenta el caso clínico de un paciente de sexo masculino de 52 años de edad, con antecedente de enfermedad de Parkinson de 10 años de evolución que se encuentra en tratamiento con levodopa-carbidopa. Acude a consultar por disminución del estado de conciencia y rigidez muscular generalizada, relacionado con el abandono de medicación 7 días antes del inicio de los síntomas. Palabras claves: síndrome neuroléptico maligno, enfermedad de Parkinson, receptores dopaminérgicos, dopaminérgicos ABSTRACTNeuroleptic malignant-like syndrome or akinetic crisis is a rare and potentially lethal complication of the withdrawal of medication of patients with Parkinson's disease. We present the clinical case of 52-year man with 10-year history of Parkinson's disease who is being treated with levodopa-carbidopa. He consults for decreased level of consciousness and general muscular rigidity, related to the withdrawal of the medication 7 days before the onset of symptoms. Keywords: neuroleptic malignant syndrome, Parkinson's disease, dopaminergic receptors, dopaminergic drugs INTRODUCCIÓNEl síndrome neuroléptico maligno (SNM) es una complicación rara, pero potencialmente letal, de la utilización de medicamentos antipsicóticos. Es el resultado de una compleja interacción entre la (1) medicación neuroléptica y alguna clase de susceptibilidad . El mecanismo fisiopatológico probablemente se deba al bloqueo de receptores de dopamina a nivel de sistema nervioso central. Esto se ha respaldado en evidencias tales como la asociación con los medicamentos cuyo mecanismo de acción es el bloqueo de receptores dopaminérgicos en el sistema nervioso central, la mayor incidencia entre más fuerte sea la

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Medical Complications of Psychiatric Treatment

Cited by 15 publications

References 65 publications

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine

Perioperative management of patients with mental diseases

Neuroleptic malignant-like síndrome

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