Medical Examiner Cases Associated With Previously Undiagnosed Diabetes Mellitus, North Carolina, 1994

Bell, Ronny A.; Howard, Dawn J.; Norman, Marilyn N.; Butts, John D.; Lengerich, Eugene J.

doi:10.1097/00007611-199802000-00006

Cited by 4 publications

(5 citation statements)

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“…World-wide, about 30 million people are thought to be affected by the disease, which is one of the leading causes of death in developed countries. A substantial percentage of individuals with diabetes are undiagnosed [1,2] and the illness is similarly under-reported on death certificates, both as an illness and cause of death [3]. The chronic complications of diabetes mellitus, mostly cardiovascular complications, followed by chronic renal disease and cerebrovascular attacks, are frequent causes of death.…”

Section: Introductionmentioning

confidence: 99%

Postmortem vitreous humor β-hydroxybutyrate: its utility for the postmortem interpretation of diabetes mellitus

Osuna

Vivero

Conejero

et al. 2005

Forensic Science International

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Section: Introductionmentioning

confidence: 99%

Postmortem vitreous humor β-hydroxybutyrate: its utility for the postmortem interpretation of diabetes mellitus

Osuna

Vivero

Conejero

et al. 2005

Forensic Science International

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“…In the Maryland study nearly 35% of cases of DKA were not known to be diabetic (26). In a study of 42 deaths from North Carolina, six cases did not have a previous diagnosis of diabetes, with five having DKA, and one case of hyperosmolar hyperglycemic state (HHS) (32).…”

Section: Discussionmentioning

confidence: 99%

Deaths From Alcoholic and Diabetic Ketoacidosis at Autopsy—A Comparison Study

Milroy¹,

Lal²,

Parai³

2023

Academic Forensic Pathology

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Diabetes mellitus and alcoholism are common disorders that may result in sudden death. Ketoacidosis may occur in both conditions. Diagnosis is based on history, and post-mortem findings including biochemistry and toxicology. This study compares deaths from alcoholic and diabetic ketoacidosis from two centres with large autopsy workloads. In the study period 9332 deaths were autopsies with 151 deaths diagnosed as ketoacidosis (1.6%) with 82 (0.9 %) being diabetic ketoacidosis (DKA) and 48 (0.5%) alcoholic ketoacidosis (AKA) deaths. There were more male deaths in each group. The median age for DKA deaths was 51 years (range 19-79). The median age for AKA deaths was 55 years (range was 34-78). The BMI range in DKA deaths was 12.5 to 40.4 kg/m2, with a median of 21.9. The comparative figures for AKA deaths was a range of 11.3 - 38.3 with a median of 20.2. Acetone concentrations were statistically higher in diabetic compared with alcoholic deaths, mean of 33.7 mg/100 mL in DKA cases versus mean of 16.9 mg/100 mL in AKA cases. Both DKA and AKA deaths are seen more commonly in males than female and are typically people with low BMIs in their 50s.

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“…Recently, a postmortem study determined that approximately, one‐third of 92 DKA‐related deaths involved patients with no previous history of DM . Another retrospective study reviewed DM‐related deaths at autopsy and discovered that of the 42 cases examined, six had no previous DM diagnosis, and five of the six had DKA . In both studies, a diagnosis of DKA was made using chemistry levels.…”

Section: Discussionmentioning

confidence: 99%

The Interplay Between Diabetes and Pancreatitis: Two Case Reports of Sudden, Natural Deaths and a Review of the Literature

Butler

Emanuel

Self

et al. 2016

Journal of Forensic Sciences

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Diabetes mellitus (DM) is a common disease involving insulin resistance or deficit that, when left unchecked, may cause severe hyperglycemia and subsequent end-organ damage. Acute pancreatitis (AP) is inflammation of the pancreas that can lead to significant morbidity and mortality. AP and DM both account for a significant amount of sudden deaths, and rarely both disease processes may be present in the same decedent, causing some difficulty in wording the cause of death statement. Although much research has been directed at studying the causes and risk factors for AP and DM, there is a complex interplay between these diseases that is not fully understood. This study presents two autopsy cases of sudden, natural deaths that illustrate this interplay, along with a review of the literature. An algorithm for differentiating AP and DM is then discussed in the context of the presented cases as a proposed aid for forensic pathologists in the certification of such deaths.

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Medical Examiner Cases Associated With Previously Undiagnosed Diabetes Mellitus, North Carolina, 1994

Cited by 4 publications

References 0 publications

Postmortem vitreous humor β-hydroxybutyrate: its utility for the postmortem interpretation of diabetes mellitus

Postmortem vitreous humor β-hydroxybutyrate: its utility for the postmortem interpretation of diabetes mellitus

Deaths From Alcoholic and Diabetic Ketoacidosis at Autopsy—A Comparison Study

The Interplay Between Diabetes and Pancreatitis: Two Case Reports of Sudden, Natural Deaths and a Review of the Literature

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