“…Automatic ROI segmentation and morphometric quantification of gray matter volume in MRI images decrease human biases and help to evaluate different groups in comparative or longitudinal studies ( Fornito et al, 2017 ; Nemoto et al, 2020 ). While traditional image processing techniques such as thresholding-based segmentation, watershed labeling, neuroanatomical-atlas-based segmentation, or semi-manual masking [using tools like FreeSurfer ( Fischl, 2012 ) or BET ( Smith, 2002 ) are available, the medical context often requires greater accuracy even on images with unclear borders or blurred definition ( Wang et al, 2023 )]. In this context, several machine learning techniques have been successfully used in analysis of complex datasets, including k-means clustering, Support Vector Machines (SVM), Random Forest, Adaptive Boosting (AdaBoost), eXtreme Gradient Boosting (XGBoost) and Deep Learning strategies like Convolutional Neural Networks (CNN), Generative Adversarial Networks (GAN), Recurrent Neural Networks (RNN) ( Wang et al, 2014 ; Zhang Z. et al, 2021 ; Verma et al, 2023 ).…”