Medical Morbidity and Mortality in Schizophrenia

Goff, Donald C.; Cather, Corinne; Evins, A. Eden; Henderson, David C.; Freudenreich, Oliver; Copeland, Paul M.; Bierer, Michael F.; Duckworth, Kenneth; Sacks, Frank M.

doi:10.4088/jcp.v66n0205

Cited by 288 publications

(174 citation statements)

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“…Research on the causes of death of psychiatric patients is a worthwhile endeavour as it has long been recognized that death rates among patients with chronic mental illnesses are higher than among the general population (Farr, 1841 ;Malzberg, 1934 ;Babigian & Odoroff, 1969 ;Harris & Barraclough, 1998 ;Sims, 2001 ;Goff et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Mortality and cause of death among psychiatric patients: a 20-year case-register study in an area with a community-based system of care

et al. 2009

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Background. Most mortality studies of psychiatric patients published to date have been conducted in hospital-based systems of care. This paper describes a study of the causes of death and associated risk factors among psychiatric patients who were followed up over a 20-year period in an area where psychiatric care is entirely provided by community-based psychiatric services.Method. All subjects in contact with the South Verona Community-based Mental Health Service (CMHS) over a 20-year period with an ICD-10 psychiatric diagnosis were included. Of these 6956 patients, 938 died during the study period. Standardized mortality ratios (SMRs) and Poisson multiple regressions were used to assess the excess of mortality in the sample compared with the general population.Results. The overall SMR of the psychiatric patients was 1.88. Mortality was significantly high among out-patients [SMR 1.71, 95 % confidence interval (CI) 1.6-1.8], and higher still following the first admission (SMR 2.61, 95 % CI 2.4-2.9). The SMR for infectious diseases was higher among younger patients and extremely high in patients with diagnoses of drug addiction (216.40, 95 % CI 142.5-328.6) and personality disorders (20.87, 95 % CI 5.2-83.4).Conclusions. This study found that psychiatric patients in contact with a CMHS have an almost twofold higher mortality rate than the general population. These findings demonstrate that, since the closure of long-stay psychiatric hospitals, the physical health care of people with mental health problems is often neglected and clearly requires greater attention by health-care policymakers, services and professionals.

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Section: Introductionmentioning

confidence: 99%

Mortality and cause of death among psychiatric patients: a 20-year case-register study in an area with a community-based system of care

et al. 2009

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“…2 Schizophrenia (SCZ) is associated with an increase of at least 50% in mortality rates compared with the general population, 3 including a suicide rate of approximately 5%, 4 resulting in a 10-year average lifespan reduction. 2 Despite recent advances, pathophysiology remains poorly understood, and current treatments remain unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia

et al. 2007

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Schizophrenia is a strongly heritable disorder, and identification of potential candidate genes has accelerated in recent years. Genomewide scans have identified multiple large linkage regions across the genome, with fine-mapping studies and other investigations of biologically plausible targets demonstrating several promising candidate genes of modest effect. The recent introduction of technological platforms for whole-genome association (WGA) studies can provide an opportunity to rapidly identify novel targets, although no WGA studies have been reported in the psychiatric literature to date. We report results of a case-control WGA study in schizophrenia, examining B500 000 markers, which revealed a strong effect (P = 3.7 Â 10 À7 ) of a novel locus (rs4129148) near the CSF2RA (colony stimulating factor, receptor 2 alpha) gene in the pseudoautosomal region. Sequencing of CSF2RA and its neighbor, IL3RA (interleukin 3 receptor alpha) in an independent case-control cohort revealed both common intronic haplotypes and several novel, rare missense variants associated with schizophrenia. The presence of cytokine receptor abnormalities in schizophrenia may help explain prior epidemiologic data relating the risk for this illness to altered rates of autoimmune disorders, prenatal infection and familial leukemia.

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“…R E V I S I Ó N evidencia de que 2/3 de la población que presenta esquizofrenia fallece por enfermedad coronaria, esto último asociado a un aumento de la prevalencia de patologías como obesidad, diabetes mellitus (DM) y dislipidemia 11,12 .…”

Section: Tabla 1 Nuevos Antipsicóticos (Atípicos) Disponibles En Chileunclassified

Alteraciones metabólicas asociadas al uso de terapia antipsicótica

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et al. 2009

Rev. méd. Chile

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Medical Morbidity and Mortality in Schizophrenia

Cited by 288 publications

References 0 publications

Mortality and cause of death among psychiatric patients: a 20-year case-register study in an area with a community-based system of care

Mortality and cause of death among psychiatric patients: a 20-year case-register study in an area with a community-based system of care

Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia

Alteraciones metabólicas asociadas al uso de terapia antipsicótica

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