Background/Aim: Appropriate decision-making in end-of-life (EOL) care is essential for both junior and senior physicians. The aim of this study was to compare the decisionmaking and attitudes of medical students with those of experienced general practitioners (GP) regarding EOL-care. Materials and Methods: A questionnaire presenting three cancer patient scenarios concerning decisions and ethical aspects of EOL-care was offered to 500 Finnish GPs and 639 graduating medical students in 2015-2016. Results: Responses were received from 222 (47%) GPs and 402 (63%) students. The GPs withdrew antibiotics (p<0.001) and nasogastric tubes (p=0.007) and withheld resuscitation (p<0.001), blood transfusions (p=0.002) and pleural drainage (p<0.001) more often than did the students. The students considered euthanasia and assisted suicide less reprehensible (p<0.001 in both) than did the GPs. Conclusion: Medical students were more unwilling to withhold and withdraw therapies in EOLcare than were the GPs, but the students considered euthanasia less reprehensible. Medical education should include aspects of decision-making in EOL-care. There is a growing demand for palliative care in Europe due to the increase in noncommunicable diseases (1). Therefore, physicians should have basic skills needed to change the goal of the treatment from life-prolonging therapies to end-of-life (EOL)-care. Appropriate decisions needed for high-quality EOL-care involve, for example, statements regarding cardiopulmonary resuscitation (CPR), hydration, and diagnostic tests. Many physician-related factors (e.g., age, experience and personal attitudes) have been shown to influence these decisions (2-4). In addition, the changing public attitudes towards EOL-care and euthanasia influence the complexity of these issues (5). The physicians' decisions regarding life-sustaining treatments vary between different treatment modalities (6-8). In a survey of American internists, blood products and haemodialysis were among the most likely withdrawn therapies, while mechanical ventilation and intravenous fluids were more commonly continued (6). Withdrawing treatment is generally experienced as more difficult than withholding them (9). The education and experience of a physician have been shown to influence decision-making in EOL-care (8, 10). Although newly-graduated physicians often feel unprepared for providing EOL-care, they face the complexity of the decision-making process just as the senior physicians (11, 12). However, the difference between graduating medical students and physicians in making these decisions remains to be studied.