Medical Use of Bismuth: the Two Sides of the Coin

Bialek, Frank Thomas Beatrix

doi:10.4172/2161-0495.s3-004

Cited by 15 publications

(13 citation statements)

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“…Regarding the bismuth-BAL complex, the mechanisms related to their antimicrobial activity are not fully understood. However, it is known that bismuth-thiols increase the permeability of the bacterial cell membrane [ 70 ]. Also, in the case of S. epidermalis , bismuth-thiol complexes reduce the glycocalyx production on the capsules [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

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Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

2020

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Background Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of BiNPs for nanomedicine-related applications. Stable Polyvinylpyrrolidone (PVP)-coated BiNPs were produced by a chemical reduction process, in less than 30 min. Results We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. The PVP-BiNPs showed potent antibacterial activity against the pathogenic bacterium Staphylococcus aureus and antifungal activity against the opportunistic pathogenic yeast Candida albicans, both under planktonic and biofilm growing conditions. Conclusions Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this facile synthetic method may allow for further investigation of their activity against a variety of pathogenic microorganisms.

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Section: Resultsmentioning

confidence: 99%

“…5 e). This may be caused by the effects of bismuth on the cells, such as the denaturing of proteins [ 68 , 69 ] and changes in the cell membrane permeability [ 70 ]. Other potential mechanisms remain to be further studied and elucidated.…”

Section: Resultsmentioning

confidence: 99%

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

2020

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“…Bismuth (Z = 83) compounds have long been used as antibacterial agents and are common today as a medication to eliminate Helicobacter pyroli, a Gram-negative bacterium that is the causative agent of gastrointestinal illnesses such as peptic ulcers [391]. Colloidal bismuth subcitrate (De-Nol) and bismuth subsalicylate (Pepto-Bismol) are used for prevention and treatement of gastric [392,393].…”

Section: Group 15: the Nitrogen Family (Pnictogens)mentioning

confidence: 99%

The elements of life and medicines

Chellan

Sadler

2015

Phil. Trans. R. Soc. A.

198

117

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Which elements are essential for human life? Here we make an element-by-element journey through the periodic table and attempt to assess whether elements are essential or not, and if they are, whether there is a relevant code for them in the human genome. There are many difficulties such as the human biochemistry of several so-called essential elements is not well understood, and it is not clear how we should classify elements that are involved in the destruction of invading microorganisms, or elements which are essential for microorganisms with which we live in symbiosis. In general, genes do not code for the elements themselves, but for specific chemical species, i.e. for the element, its oxidation state, type and number of coordinated ligands, and the coordination geometry. Today, the biological periodic table is in a position somewhat similar to Mendeleev's chemical periodic table of 1869: there are gaps and we need to do more research to fill them. The periodic table also offers potential for novel therapeutic and diagnostic agents, based on not only essential elements, but also non-essential elements, and on radionuclides. Although the potential for inorganic chemistry in medicine was realized more than 2000 years ago, this area of research is still in its infancy. Future advances in the design of inorganic drugs require more knowledge of their mechanism of action, including target sites and metabolism. Temporal speciation of elements in their biological environments at the atomic level is a major challenge, for which new methods are urgently needed.

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“…Regarding the bismuth-BAL complex, the mechanisms related to their antimicrobial activity are not fully understood. However, it is known that bismuth-thiols increase the permeability of the bacterial cell membrane [61]. Also, in the case of S. epidermalis , bismuth-thiol complexes reduce the glycocalyx production on the capsules [58].…”

Section: Resultsmentioning

confidence: 99%

“…5E ). This may be caused by the effects of bismuth on the cells, such as the denaturing of proteins [59,60] and changes in the cell membrane permeability [61]. Other potential mechanisms remain to be further studied and elucidated.…”

Section: Resultsmentioning

confidence: 99%

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity againstStaphylococcus aureusandCandida albicans

Vázquez-Muñoz

Arellano-Jimenez

Lopez-Ribot

2020

Preprint

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19Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of 20 bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of 21BiNPs for nanomedicine, particularly as a disinfectant and for future treatments. Stable PVP-coated BiNPs were 22 produced by a chemical reduction process, in less than 30 minutes, in a heated alkaline glycine solution, by the 23 chelation and reduction of the bismuth (III) ion; resulting in the generation of small, spheroid particles with a 24 crystalline organization. We assessed the antibacterial and antifungal activity of bismuth nanoparticles. PVP-25BiNPs showed potent antibacterial activity against the pathogenic bacterium Staphylococcus aureus and 26 antifungal activity against the opportunistic pathogenic yeast Candida albicans, both under planktonic and biofilm 27 growing conditions. Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this 28 facile synthetic method may allow for further investigation of their activity against a variety of pathogenic 29 microorganisms. 30 31 for years) [1,2]. Bismuth is insoluble in water but soluble in some organic solutions. The water-solubility and 36 lipophilicity of bismuth can be enhanced when it is complexed with lipophilic molecules [3] and its biocompatibility 37 is increased when it is chelated with hydroxyl or sulfhydryl groups. Bismuth compounds have been used in 38 medicine for more than two centuries [4]. Bismuth subsalicylate is utilized to treat diarrhea-related ailments since 39 the 1900s [5], and most recently, bismuth compounds have been used in computed tomography imaging and 40anti-cancer therapy [6,7]. In the U.S., around 30% of the bismuth compounds are used for cosmetic and 41 pharmaceutical applications [4]. 42Several bismuth compounds display antibacterial and antifungal activity [8,9], and can outperform the inhibitory 43 activity of conventional antibiotics [10]. When bismuth is thiolated, such as in the case of bismuth-thiols (BTs) 44 complexes, its antimicrobial activity is further enhanced [11]. Bismuth-dimercaptopropanol (bismuth-BAL) and 45other BTs display anti-biofilm activity [12]. Additionally, the thiolation of bismuth complexes increases their 46 stability [13]; however, BTs stability is still relatively low when compared to other antimicrobial agents [14]. 47 of synthesis, as follows: High-Resolution Transmission Electron Microscopy (HR-TEM) for determining the 96 single-particle structural lattice, using Selected-Area Electron Diffraction (SAED) analysis. The PVP-BiNPs, 97 deposited on Type-B carbon-coated copper grids (Ted Pella Inc.), were examined in a JEOL 2010-F HR-TEM 98 (Jeol Ltd.), with 200 kV accelerating voltage. Dynamic Light Scattering analysis to determine the hydrodynamic 99 size, using a Zetasizer Nano ZS (Malvern Panalytical). PVP-BiNPs were diluted in Milli Q water and then 100 transferred to a DTS1070 cell for the analysis. UV-Vis spectroscopy to follow...

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Medical Use of Bismuth: the Two Sides of the Coin

Abstract: Jour n a l o f C linical T o x ic o log y

Cited by 15 publications

References 53 publications

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

The elements of life and medicines

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity againstStaphylococcus aureusandCandida albicans

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