Medication adherence among HIV+ adults

Hinkin, Charles H.; Castellon, Steven A.; Durvasula, Ramani; Hardy, David; Lam, Mona; Mason, Karen I.; Thrasher, D.; Goetz, Matthew Bidwell; Stefaniak, Marta

doi:10.1212/01.wnl.0000038347.48137.67

Cited by 414 publications

(357 citation statements)

References 46 publications

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“…This study supports and extends previous reports regarding the everyday life significance of NP impairments associated with HIV infection (Albert et al, 1995;Heaton et al, 1996;Hinkin et al, 2002;Marcotte et al, 1999;Stern et al, 1991). It is the largest such study to date and the most comprehensive in its coverage of both performance-based measures of IADLs and manifest measures of daily functioning outside of the laboratory.…”

Section: Discussionsupporting

confidence: 89%

“…However, a limitation of the current study is that it did not include a measure of participants' accuracy in following their own antiretroviral medication regimens. For example, Hinkin et al (2002) have used electronic monitoring technology (MEMS caps) to track medication use in HIV infected adults, and found that those who were NP-impaired evidenced worse adherence to their prescribed regimens. Future research with laboratory based medication management tasks should seek to validate them using MEMS caps or other objective methods of assessing adherence.…”

Section: Discussionmentioning

confidence: 99%

“…Of particular importance to HIV1 patients is the ability to effectively manage their antiretroviral medications. Preliminary studies suggest that HIV1 participants with impairments in memory, executive function, and psychomotor functioning can demonstrate significant difficulties with performance on structured tasks of medication management ability, as well as adherence to medication regimens in everyday life (Albert et al, 1999;Hinkin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

681

689

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HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or "real-world" impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction0Executive Function, Learning, Attention0Working Memory and Verbal abilities most strongly and consistently predicted failures on the functional battery. Both NP impairment and impairment on the functional battery were significantly associated with subjective experiences of cognitive difficulties, as well as unemployment and increased dependence in activities of daily living; multivariate prediction models that also considered depressed mood and biological measures of disease progression revealed that impairment on the functional battery and depression were the only unique predictors of all three indicators of "real-world" functioning. The current results add to growing evidence concerning the clinical significance of HIV-associated NP impairment. Objective, laboratory based functional measures, such as those used here, may compliment NP testing in future studies directed at understanding the impact on life quality of central nervous system disorders and their treatments. Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons. (JINS, 2004, 10, 317-331.)

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

681

689

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“…It is also possible that HIV-associated neurocognitive disturbances, which are common and more prominent as the disease advances, might be responsible for some of the cases of poor medication adherence. Other studies have reported a significantly greater risk of poor adherence to HAART in HIVinfected persons with neurocognitive impairment (Hinkin et al 2002). Depression has been associated with immune suppression and other health outcomes in studies of individual with and without chronic disease (; Herbert & Cohen 1993;Rover et al, 1991).…”

Section: Consequences Of Neuropsychiatric Problems In Patients With Hmentioning

confidence: 97%

Neuropsychiatric Manifestations of HIV Infection and AIDS

Olisah¹

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

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“…A presença do HIV-1 no SNC pode ser a principal responsável pelas manifestações neuropsicológicas e por alterações na qualidade de vida do indivíduo (Hinkin et al, 2002;Mehan & Brush, 2001;Odiase, Ogurin & Ogunniyi, 2007). Estas ocorrem como distúrbios de diversos graus nas áreas motora, comportamental e cognitiva (Vitiello et al, 2007 Nos estágios precoces do complexo demencial da AIDS, os resultados de exames neurológicos podem ser normais (Cohen, Perlstein & Braver, 1997;MacArthur et al, 2003).…”

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Estudo dos transtornos cognitivos decorrentes da infecção pelo HIV-1

Kalil

Alvarenga

Almeida

et al. 2009

Estud. psicol. (Campinas)

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A infecção pelo vírus da imunodeficiência humana atinge o Sistema Nervoso Central nos estágios iniciais, causando manifestações neuropsicológicas. Com o objetivo de estudar o desempenho de indivíduos infectados por este vírus em relação às funções cognitivas, foram avaliados 20 pacientes com contagem de linfócitos CD4+ acima de 200 células/mm³, utilizando-se a Escala de Inteligência Wechsler para Adultos. Destes, cinco (25%) eram do sexo masculino e 15 (75%) do sexo feminino, com média de idade de 39,65 desvio-padrão de 10,15 anos. A contagem média de linfócitos CD4+ foi 467,20 desvio-padrão de 215,45 células/mm?. Dentre quatorze pacientes que fizeram uso de terapia antirretroviral de alta atividade foi observado um caso com desempenho das funções cognitivas atenção e aprendizagem muito abaixo da média; os demais (n=13) tiveram desempenho dentro da média. Por meio da Escala de Inteligência Wechsler para Adultos foi possível detectar desempenho abaixo do nível médio do funcionamento cognitivo em indivíduos com resultado positivo para vírus da imunodeficiência humana, mesmo em vigência de terapia antirretroviral de alta atividade.

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Medication adherence among HIV+ adults

Abstract: HIV-infected adults with significant neurocognitive compromise are at risk for poor medication adherence, particularly if they have been prescribed a complex dosing regimen. As such, simpler dosing schedules for more cognitively impaired patients might improve adherence.

Cited by 414 publications

References 46 publications

The impact of HIV-associated neuropsychological impairment on everyday functioning

The impact of HIV-associated neuropsychological impairment on everyday functioning

Neuropsychiatric Manifestations of HIV Infection and AIDS

Estudo dos transtornos cognitivos decorrentes da infecção pelo HIV-1

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