Medication Effects on Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Fetal Alcohol Spectrum Disorder

Doig, Jenna; McLennan, John D.; Gibbard, W. Ben

doi:10.1089/cap.2007.0121

Cited by 77 publications

(51 citation statements)

References 26 publications

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“…This was the premise for a few clinical studies using psychostimulant drugs like Dextroamphetamine and Methylphenidate for FASD, especially in cases of FASD and symptoms of hyperactivity and inattention. O'Malley et al [8], Doig et al [17], Infante et al [31], Snyder et al [20], and Oesterheld et al [28] reported clinical studies to delineate the best stimulant therapy for FASD with symptoms of hyperactivity and inattention. The outcomes of these studies gave mixed yet uncertain verdicts for the use of these psychostimulants.…”

Section: Discussionmentioning

confidence: 99%

“…The outcomes of these studies gave mixed yet uncertain verdicts for the use of these psychostimulants. In these studies, inattention was found to respond better to Dextroamphetamine than Methylphenidate, but a high adverse event profile induced discontinuation [17,28]. Dextroamphetamine was deduced as preferred given its action on the D1 receptors.…”

Section: Discussionmentioning

confidence: 99%

“…A reference list of 10 randomly selected relevant articles (Doig et al [17]; Frankel et al [4]; Hagerman [6]; Ipsiroglu et al [3]; Kodituwakku [11]; Koren [2]; O'Malley and Nanson [9]; Ozsarfati and Koren [18]; Rowles and Findling [19]; Snyder et al [20]) was manually hand-searched to identify any further article that may be relevant. A snowball technique was also adopted, where citations within articles were searched if they appeared relevant to the systematic review (Ji and Findling [21]; Huizink [7]).…”

Section: Data Sources and Search Strategymentioning

confidence: 99%

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The utility of psychotropic drugs on patients with Fetal Alcohol Spectrum Disorder (FASD): a systematic review

Mela

Okpalauwaekwe

Anderson

et al. 2018

Psychiatry and Clinical Psychopharmacology

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BACKGROUND: Treatment of the complications arising from Prenatal Alcohol Exposure (PAE) has largely been focused on psychosocial and environmental approaches. Research on the use of medications, especially psychotropic medications, has lagged behind. OBJECTIVES: This systematic review sought to investigate psychotropic medication related findings and outcomes in those diagnosed with Fetal Alcohol Spectrum Disorder (FASD). METHODS: Comprehensive searches were conducted in seven major databases (Medline/ PubMed, Scopus, Web of Knowledge, Embase, PsycINFO, Cochrane Library, and PsycARTICLES) up to February 2017. Key search terms with synonyms were mapped on these databases. There were no timeline restrictions and no grey literature searches. Two reviewers independently assessed 25 studies that met the inclusion criteria. Most studies were reviews of treatment and retrospective case series. RESULTS: Two crossover randomized trials were reported, and the findings were not amenable to meta-analysis. Several conditions (depression, agitation, seizures, and outburst) combined with the most frequent presentation, ADHD, to represent the rationale for prescribing psychotropic medications. Second-generation antipsychotics were found to improve social skills, but the paucity of data limited the extent of clinical guidance necessary for the field. CONCLUSIONS: The systematic review showed that there are some clinical evidence displaying the validity of psychopharmacological interventions in people with FASD, which varies across the spectrum of disease severity, age, and gender. There is a need for more clinical evidencebased studies in addition to clinical expert opinions to substantiate an optimal ground for individualized management of FASD.The study protocol for this review was registered in PROSPERO with registration number CRD42016045703.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Data Sources and Search Strategymentioning

confidence: 99%

See 1 more Smart Citation

The utility of psychotropic drugs on patients with Fetal Alcohol Spectrum Disorder (FASD): a systematic review

Mela

Okpalauwaekwe

Anderson

et al. 2018

Psychiatry and Clinical Psychopharmacology

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“…However, a significant number of the trials (approximately one third) had to be stopped due to concerns regarding negative side effects. Most recently, Doig et al [2008] reviewed 41 medication trials in a sample of 27 children diagnosed with an FASD and ADHD. The majority of the trials consisted of stimulant medications, although some included combinations of psychostimulants with other medications, such as clonidine, risperidone, or carbamazepine, Significant effects were seen on all three domains of the MTA-SNAP-IV, although more children received normalized scores in the hyperactive/ impulsive and oppositional/defiant domains than in the inattentive domain.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

Intervention for individuals with fetal alcohol spectrum disorders: Treatment approaches and case management

Paley¹,

O’Connor²

2009

Dev Disabil Res Revs

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Exposure to alcohol in utero is considered to be the leading cause of developmental disabilities of known etiology. The most severe consequence of such exposure, fetal alcohol syndrome (FAS), is characterized by a distinct constellation of characteristic facial anomalies, growth retardation, and central nervous system (CNS) dysfunction. Some individuals with prenatal alcohol exposure (PAE) do not meet the full criteria for FAS, but instead are diagnosed with partial FAS, alcohol related neurodevelopmental disorder (ARND), or alcohol related birth defects (ARBD). The entire continuum of effects from PAE is increasingly being referred to under the umbrella term of fetal alcohol spectrum disorders (FASDs). An extensive body of research has documented major cognitive, behavioral, adaptive, social, and emotional impairments among individuals with FASDs. Although FAS was identified in the U.S. over 35 years ago, the development, evaluation, and dissemination of evidencebased interventions for individuals with FASDs have lagged behind significantly. Encouragingly, however, in recent years there has been a marked increase in efforts to design and test interventions to remediate the impairments associated with prenatal alcohol exposure. This article will review treatment needs and considerations for individuals with FASDs and their families, current empirically tested treatment approaches, case management issues, and suggestions for future directions in research on the treatment of FASDs. ' 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 200915:258-267.

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“…Both of these studies with medication and FASD were limited by very small sample sizes that impacts power and generalizability, as well as insufficient information on dosing and medication compliance. Doig et al [52] examined the effects of medication on ADHD symptoms in a larger sample (n=27) of children (aged 5 to 14 years) with FASD and found that children with FASD tended to showed more normalized scores on teacher-rated hyperactivity/impulsivity and opposition/defiance than inattention, indicating a different pattern of response than is reported for otherwise typically developing children.…”

Section: Medical Interventionsmentioning

confidence: 99%

Interventions for Fetal Alcohol Spectrum Disorder: Meeting Needs Across the Lifespan

Pei¹,

Flannigan²,

Walls³

et al. 2016

Int J Neurorehabilitation Eng

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Background: Fetal Alcohol Spectrum Disorder (FASD) is a complicated disability resulting in a diverse, highneeds population for whom intervention is critical to optimize functional competence and reduce the emergence of adverse outcomes. Researchers have been evaluating intervention efforts for FASD to inform practice and policy decision-making. Objective: The current review provides a synopsis of the current state of evidence for intervention research in FASD, with consideration of how our growing understanding of the unique needs of individuals with FASD might inform future intervention initiatives. Method: A comprehensive literature review was conducted across a number of databases using multiple search terms linking FASD and intervention. Results: Existing evidence-based interventions are limited and focus predominantly on the school-aged population, thereby neglecting adolescents and adults. Future research efforts are needed to support individuals with FASD across the entire lifespan, particularly during transitions and for individuals involved in the legal system. Conclusion: As the field of FASD continues to grow, so must the quality and quantity of intervention research. It is through cross-discipline intervention research efforts that the evidence supporting best practices will be established, and policies can be implemented to reflect best uses of available funds to support this population.

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Medication Effects on Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Fetal Alcohol Spectrum Disorder

Cited by 77 publications

References 26 publications

The utility of psychotropic drugs on patients with Fetal Alcohol Spectrum Disorder (FASD): a systematic review

The utility of psychotropic drugs on patients with Fetal Alcohol Spectrum Disorder (FASD): a systematic review

Intervention for individuals with fetal alcohol spectrum disorders: Treatment approaches and case management

Interventions for Fetal Alcohol Spectrum Disorder: Meeting Needs Across the Lifespan

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