Medication Strategies for the Male with Unexplained Infertility

Starks, Christopher; Sabanegh, Edmund

doi:10.1007/978-1-4939-2140-9_24

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…The use of androgen treatment in cases of idiopathic male infertility can lead to a direct effect [30] and a rebound effect [31,32]. The direct effect means that low-dose androgen application improves epididymal sperm maturation directly; while the rebound effect occurs after stopping androgen supplementation.…”

Section: Discussionmentioning

confidence: 99%

The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels

Thanaboonyawat,

Chera-aree,

Petyim

et al. 2020

Clin. Exp. Obstet. Gynecol.

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Objective: The effects of daily topical application of testosterone gel on semen characteristics in infertile men with oligozoospermia and hypogonadism were assessed. Methods: Sixteen infertile men were included in this prospective study. A daily morning application of 25 mg transdermal testosterone (T) gel was used for 3 months. Semen parameters, serum follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E) and T levels, and seminal plasma E and T levels were measured before treatment and once monthly for three months during the therapy. Results: The baseline median sperm concentration was 5.5 × 106/mL. Median sperm concentrations at the first, second and third months were 9 × 106, 8 × 10 6, and 4 × 106/mL, respectively. The sperm concentrations at the first and second months after starting therapy significantly (p < 0.001) increased compared with the baseline. However, sperm volume, pH, motility, viability and morphology were similar to baseline. Serum T significantly (p < 0.001) increased, while serum FSH significantly (p < 0.001) decreased from baseline. Seminal T and T/E ratios were raised significantly (p = 0.008 and p = 0.004, respectively) after gel application, whereas the seminal E level was not affected. Conclusions: Daily 25 mg T gel applications for oligospermic infertile men with hypogonadism increased the sperm concentration at the first and second months and raised the serum T level to the normal adult male range. Nevertheless, the sperm concentration had a decreasing trend after the third month.

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Section: Discussionmentioning

confidence: 99%