Medications With Depression as an Adverse Effect

Agustini, Bruno; Berk, Michael

doi:10.1001/jama.2018.12390

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The strengths of this study include a much larger and well-characterised sample of community-dwelling older adults compared with previous studies, a comprehensive assessment of individuals, well-validated instruments for depression assessment, and a strict protocol of three BP measures taken by trained professionals. The exclusion of nonhypertensive participants significantly contributes to reduce confounding by indication effects, although these cannot be excluded with this study design [38]. Accounting for a variety of confounders, including metabolic and sociodemographic factors previously associated with depression, in well-powered multivariable models was another advantage.…”

Section: Discussionmentioning

confidence: 99%

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

et al. 2020

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Section: Discussionmentioning

confidence: 99%

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

et al. 2020

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“…After these factors were taken into consideration in our study, and after subgroup analyses, the increased prevalence of depression in statin users was no longer statistically significant. Such confounding by indication is an important factor in other conditions and medications linked with possible neuropsychiatric adverse events [35, 36]. To address this issue, we performed multivariate analyses for all significant confounding factors associated with depression in our sample, one of the main strengths of this study.…”

Section: Discussionmentioning

confidence: 99%

Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study

et al. 2019

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“…The iatrogenic depressant effects of medications used to treat chronic medical illness (e.g. barbiturates, vigabatrin, topiramate, flunarizine, corticosteroids, mefloquine, beta blockers [association more recently questioned], efavirenz, interferon-α) may also have a relevant role (Agustini and Berk, 2018;Celano et al, 2011;Machado et al, 2017).…”

Section: Epidemiology and Pathogenesismentioning

confidence: 99%

Depression in the medically ill

Rosenblat

Kurdyak

Cosci

et al. 2019

Aust N Z J Psychiatry

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Background: Depressive disorders are significantly more common in the medically ill compared to the general population. Depression is associated with worsening of physical symptoms, greater healthcare utilization and poorer treatment adherence. The present paper provides a critical review on the assessment and management of depression in the medically ill. Methods: Relevant articles pertaining to depression in the medically ill were identified, reviewed and synthesized qualitatively. A systematic review was not performed due to the large breadth of this topic, making a meaningful summary of all published and unpublished studies not feasible. Notable studies were reviewed and synthesized by a diverse set of experts to provide a balanced summary. Results: Depression is frequently under-recognized in medical settings. Differential diagnoses include delirium, personality disorders and depressive disorders secondary to substances, medications or another medical condition. Depressive symptoms in the context of an adjustment disorder should be initially managed by supportive psychological approaches. Once a mild to moderate major depressive episode is identified, a stepped care approach should be implemented, starting with general psychoeducation, psychosocial interventions and ongoing monitoring. For moderate to severe symptoms, or mild symptoms that are not responding to low-intensity interventions, the use of antidepressants or higher intensity psychotherapeutic interventions should be considered. Psychotherapeutic interventions have demonstrated benefits with small to moderate effect sizes. Antidepressant medications have also demonstrated benefits with moderate effect sizes; however, special caution is needed in evaluating side effects, drug–drug interactions as well as dose adjustments due to impairment in hepatic metabolism and/or renal clearance. Novel interventions for the treatment of depression and other illness-related psychological symptoms (e.g. death anxiety, loss of dignity) are under investigation. Limitations: Non-systematic review of the literature. Conclusion: Replicated evidence has demonstrated a bidirectional interaction between depression and medical illness. Screening and stepped care using pharmacological and non-pharmacological interventions is merited.

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Medications With Depression as an Adverse Effect

Abstract: and Janssen Cilag; and having a number of patents pending for agents for psychiatric or central nervous system disorders. No other disclosures were reported.

Cited by 4 publications

References 5 publications

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study

Depression in the medically ill

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