Medicinal and Edible Plants as Cancer Preventive Agents

Yasukawa, Ken

doi:10.5772/34545

Cited by 16 publications

(7 citation statements)

References 84 publications

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“…However, the adult population bears tumour cells that cannot revert to normal cells, and thus effective strategies to prevent cancer include avoiding continuous contact between these cells and promoters and/or aggressively inhibiting the tumour promoter effects. Therefore, to prevent cancer, it is essential to find plants that contain effective compounds (anti-tumour promoters) that delay, inhibit or block tumour promotion, which is a reversible and long-term process (Yasukawa, 2012) Prostate cancer is a very good example for chemoprevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. The extract of the bark of Pygeum africanum (Prunus Africana) has been used in Europe as a prevention and treatment of prostate disorders including benign prostatic hypertrophy (BPH).…”

Section: Figure 6: Stages In Cancer Prevention Researchmentioning

confidence: 99%

The role and place of medicinal plants in the strategies for disease prevention

Sofowora

Ogunbodede

Onayade

2013

Afr. J. Trad. Compl. Alt. Med.

619

428

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Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This paper discusses the role, contributions and usefulness of medicinal plants in tackling the diseases of public health importance, with particular emphasis on the current strategic approaches to disease prevention. A comparison is drawn between the 'whole population' and 'high-risk' strategies. The usefulness of the common-factor approach as a method of engaging other health promoters in propagating the ideals of medicinal plants is highlighted. The place of medicinal plants in preventing common diseases is further examined under the five core principles of the Primary Health Care (PHC) approach. Medicinal plants play vital roles in disease prevention and their promotion and use fit into all existing prevention strategies. However, conscious efforts need to be made to properly identify, recognise and position medicinal plants in the design and implementation of these strategies. These approaches present interesting and emerging perspectives in the field of medicinal plants. Recommendations are proposed for strategising the future role and place for medicinal plants in disease prevention.

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Section: Figure 6: Stages In Cancer Prevention Researchmentioning

confidence: 99%

The role and place of medicinal plants in the strategies for disease prevention

Sofowora

Ogunbodede

Onayade

2013

Afr. J. Trad. Compl. Alt. Med.

619

428

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“…Cancer prevention is a major public health issue worldwide. We previously reported the inhibition of tumour promotion in mouse skin using components from plants and fungi [1,2].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Ginseng (Panax ginseng) Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA

Yasukawa

Whang

2016

J. Nutr. Ther.

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Cancer prevention is a major issue in the field of public health. Ethanol extracts of the ginseng berry were found to inhibit the inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumour promoter. The extracts also inhibited tumour promotion by TPA in the mouse skin two-stage carcinogenesis model. The major components, ginsenosides Rd (3) and Re (4), inhibited inflammation induced by TPA in mice, while protopanaxadiol (1) and protopanaxatriol (2), the aglycones of these ginsenosides, markedly inhibited TPA-induced inflammatory ear oedema in mice. The inhibitory effects of these compounds were more potent than those of indomethacin.

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“…Cancer prevention is an important issue for human health worldwide. We have previously reported the inhibition of tumour promotion induced by 12-Otetradecanoylphorbol-13-acetate (TPA) following initiation with 7,12-dimethylbenz[a]anthracene (DMBA) in mouse skin by various components from plants and fungi [1,2]. Solidago, commonly known as goldenrod, is a genus comprising 100 to 120 species of flowering plants in the aster family, Asteraceae.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete

Yasukawa

2015

J. Nutr. Ther.

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Cancer prevention is an important issue in various healthcare fields; thus, we continue searching for potential useful compounds. This study focuses on the utilization of Canadian goldenrod, which is commonly seen growing on vacant land. Methanol extracts of the flower of Canadian goldenrod inhibited inflammation by 12-Otetradecanoylphorbol-13-acetate (TPA) and inhibited promotion in the mouse skin two-stage carcinogenesis model. Five inhibitory compounds were isolated from the active fraction, and these compounds were identified as flavonoids; kaempferol (1), quercetin (2), kaempferol-3-O-rutinoside (3), querectin-3-O-rutinoside (4), and isorhamnetin-3-Orutinoside (5). These compounds inhibited the inflammation induced by TPA, and the inhibitory effects were similar to indomethacin.

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Medicinal and Edible Plants as Cancer Preventive Agents

Cited by 16 publications

References 84 publications

The role and place of medicinal plants in the strategies for disease prevention

The role and place of medicinal plants in the strategies for disease prevention

Inhibitory Effects of Ginseng (Panax ginseng) Berry on Tumour Promotion and Inflammatory Ear Oedema Induced by TPA

Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete

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