Medicinal Importance of Gallic Acid and Its Ester Derivatives: a Patent Review

Choubey, Sneha; Varughese, Lesley Rachel; Kumar, Vinod; Beniwal, Vikas

doi:10.4155/ppa.15.14

Cited by 249 publications

(132 citation statements)

References 23 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…The quantity of phenylalanine present in T. populnea was at par with that reported in S. persica fruit (Kumari et al, ). Phenylalanine is an essential aromatic amino acid required for the synthesis of other amino acids, neurotransmitters like catecholamine (Bhagavan & Ha, ), and various antioxidant compounds such as gallic acid, caffeic acid, and protocatechuic acid (Choubey, Varughese, Kumar, & Beniwal, ). Moreover, other amino acids like leucine, isoleucine, and valine were also present in sufficient amounts in T. populnea.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical profiling, polyphenol composition, and antioxidant activity of the leaf extract from the medicinal halophyteThespesia populneareveal a potential source of bioactive compounds and nutraceuticals

et al. 2018

View full text Add to dashboard Cite

The present study evaluated the phytochemical constituents, nutritional attributes, and the antioxidant capacity of the medicinal halophyte Thespesia populnea. The metabolite profiling by GC‐QTOF‐MS analysis identified 37 metabolites among which sucrose, malic acid, and turanose were the most abundant. A total of 18 polyphenols and 17 amino acids were identified by the HPLC‐DAD analysis. The most abundant polyphenols in T. populnea were gallic acid, catechin, and myricetin. Other polyphenols like protocatechuic acid, epigallocatechin gallate, rosmarinic acid, ellagic acid, rutin, and naringenine were also detected in ample amounts. The leaf extract demonstrated higher antioxidant as well as lipid peroxidation inhibition activities. A correlation analysis revealed a positive correlation between the antioxidant capacity and the phenolic compounds viz. gallic acid, catechin, myricetin, quercetin, apigenin, cinnamic acid, and coumarin which indicates that these phenolic compounds are the main contributors of the antioxidant potential of T. populnea. The results of this study establish T. populnea as a potential source of nonconventional functional food. Practical applications The data presented here indicate that T. populnea can be considered as a nonconventional functional food and potential source of energy, antioxidants, minerals, essential amino acids, and bioactive compounds in herbal formulations, food supplements, or nutraceuticals. The metabolites identified from this halophyte have pharmacological and nutraceutical potentials, suggesting T. populnea as an ideal candidate for application in the food and phytopharmaceutical industries to produce health‐promoting products, functional foods, and herbal medicines.

show abstract

Section: Resultsmentioning

confidence: 99%

Phytochemical profiling, polyphenol composition, and antioxidant activity of the leaf extract from the medicinal halophyteThespesia populneareveal a potential source of bioactive compounds and nutraceuticals

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Many healthy properties are ascribed to gallic acid, including antioxidant, neuroprotective and antimicrobial effects [61,62,63]. This non-flavonoid compound was identified in all samples, with the exception of CR1 (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials

et al. 2016

View full text Add to dashboard Cite

Biomaterials releasing bactericides have currently become tools for thwarting medical device-associated infections. The ideal anti-infective biomaterial must counteract infection while safeguarding eukaryotic cell integrity. Red wine is a widely consumed beverage to which many biological properties are ascribed, including protective effects against oral infections and related bone (osteoarthritis, osteomyelitis, periprosthetic joint infections) and cardiovascular diseases. In this study, fifteen red wine samples derived from grapes native to the Oltrepò Pavese region (Italy), obtained from the winemaking processes of “Bonarda dell’Oltrepò Pavese” red wine, were analyzed alongside three samples obtained from marc pressing. Total polyphenol and monomeric anthocyanin contents were determined and metabolite profiling was conducted by means of a chromatographic analysis. Antibacterial activity of wine samples was evaluated against Streptococcus mutans, responsible for dental caries, Streptococcus salivarius, and Streptococcus pyogenes, two oral bacterial pathogens. Results highlighted the winemaking stages in which samples exhibit the highest content of polyphenols and the greatest antibacterial activity. Considering the global need for new weapons against bacterial infections and alternatives to conventional antibiotics, as well as the favorable bioactivities of polyphenols, results point to red wine as a source of antibacterial substances for developing new anti-infective biomaterials and coatings for biomedical devices.

show abstract

“…29 Furthermore, gallic acid has been shown as a potent compound with antimicrobial, antioxidant, quorum-sensing inhibitory and anti-cancer properties. [30][31][32] In the current study, the tested compounds had no measurable effects on human fibroblast cells. This may suggest that these compounds are non-toxic, although alternatively this could indicate that fibroblasts are very resistant compared to the MCF-7 breast cancer cell line.…”

Section: Discussionmentioning

confidence: 99%

Screening for Anti-Cancer Compounds in Marine Organisms in Oman

Dobretsov

Tamimi

Al-Kindi

et al. 2016

SQUMJ

View full text Add to dashboard Cite

Objectives: Marine organisms are a rich source of bioactive molecules with potential applications in medicine, biotechnology and industry; however, few bioactive compounds have been isolated from organisms inhabiting the Arabian Gulf and the Gulf of Oman. This study aimed to isolate and screen the anti-cancer activity of compounds and extracts from 40 natural products of marine organisms collected from the Gulf of Oman. Methods: This study was carried out between January 2012 and December 2014 at the Sultan Qaboos University, Muscat, Oman. Fungi, bacteria, sponges, algae, soft corals, tunicates, bryozoans, mangrove tree samples and sea cucumbers were collected from seawater at Marina Bandar Al-Rowdha and Bandar Al-Khayran in Oman. Bacteria and fungi were isolated using a marine broth and organisms were extracted with methanol and ethyl acetate. Compounds were identified from spectroscopic data. The anti-cancer activity of the compounds and extracts was tested in a Michigan Cancer Foundation (MCF)-7 cell line breast adenocarcinoma model. Results: Eight pure compounds and 32 extracts were investigated. Of these, 22.5% showed strong or medium anti-cancer activity, with malformin A, kuanoniamine D, hymenialdisine and gallic acid showing the greatest activity, as well as the soft coral Sarcophyton sp. extract. Treatment of MCF-7 cells at different concentrations of Sarcophyton sp. extracts indicated the induction of concentration-dependent cell death. Ultrastructural analysis highlighted the presence of nuclear fragmentation, membrane protrusion, blebbing and chromatic segregation at the nuclear membrane, which are typical characteristics of cell death by apoptosis induction. Conclusion: Some Omani marine organisms showed high anti-cancer potential. The efficacy, specificity and molecular mechanisms of anti-cancer compounds from Omani marine organisms on various cancer models should be investigated in future in vitro and in vivo studies.

show abstract

Medicinal Importance of Gallic Acid and Its Ester Derivatives: a Patent Review

Cited by 249 publications

References 23 publications

Phytochemical profiling, polyphenol composition, and antioxidant activity of the leaf extract from the medicinal halophyteThespesia populneareveal a potential source of bioactive compounds and nutraceuticals

Phytochemical profiling, polyphenol composition, and antioxidant activity of the leaf extract from the medicinal halophyteThespesia populneareveal a potential source of bioactive compounds and nutraceuticals

Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials

Screening for Anti-Cancer Compounds in Marine Organisms in Oman

Contact Info

Product

Resources

About