Medicinal Plants for Management of Gastroesophageal Reflux Disease: A Review of Animal and Human Studies

Abstract

The multiple mechanisms of action of medicinal plants in GERD other than anti-secretory properties appear to provide more efficient treatment and helped to manage the histopathological changes associated with this disorder. Further studies are needed to understand the effects of medicinal plants on GERD better.

The Effect of Myrtus communis L. Syrup in Reducing the Recurrence of Gastroesophageal Reflux Disease: A Double-Blind Randomized Controlled Trial

“…In another study showed that rikkunshito, a traditional Japanese multi-herbal medicine, caused significant improvement in PPI-refractory reflux disease. In this study has shown to have a similar effect on PPI-refractory reflux disease (36). Myrtle possesses astringent, carminative, demulcent, analgesic, antiseptic and anti-inflammatory features (24).…”

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

“…The prerequisite to screen/study any medicinal compound for its hepatoprotective activity is to develop a model (animal model or cell culture model) in which hepatic injury is induced (Salehi, Karegar‐Borzi, Karimi, & Rahimi, ). Several studies have manipulated mice models to induce hepatotoxicity and then treat those induced liver diseases using herbs and herbal products (Figure ).…”

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options

“…The medicinal plants and herbal preparations with antioxidant and anti-inflammatory mechanisms include Curcuma longa , Panax quinquefolium, Artemisia asiatica , and Lonicera japonica . Moreover, other mechanisms include: the down-regulation of the genes encoding proteins that have key role in acute inflammation, including 1 intercellular adhesion molecule-1 (ICAM-1) and cytokine-induced neutrophil chemoattractant-2-beta (CINC-2-2 beta) ( Panax quinquefolium ); ameliorating the function and gastric mucus ( Morus alba, Curcuma longa ); reducing gastric acid, such as for instance Curcuma longa , Morus alba , and acidinol syrup, increasing tonic contractions of the lower esophageal sphincter (LES) ( Salvia miltiorrhiza , STW 5), and preventing the pro-inflammatory cytokines IL-1 b and TNF-a (STW 5) [99].…”