Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options

Kuna, Lucija; Jakab, Jelena; Stoehr, Robert; Raguž-Lučić, Nikola; Včev, Aleksandar; Smolić, Martina

doi:10.3390/jcm8020179

Cited by 248 publications

(181 citation statements)

References 105 publications

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“…Peptic ulcer disease (PUD) is best defined as a peptic injury of the alimentary tract that occurs in the stomach or the proximal duodenum, as a secondary to the damaging effects of pepsin, active free radicals, oxidants, leukotrienes, endothelins, and stomach acid secretion. This subsequently leads to a mucosal defect reaching the submucosa or muscularis propria [1,2]. The estimated prevalence of PUD in the general population is approximately 4.1%, and 10% of people develop PUD during the course of a lifetime [3].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

et al. 2020

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Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-3 oil gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the oil omega-3 (X1, 10–30%), the surfactant tween 20 and Kolliphor mixture (X2, 20–40%), and the cosurfactant transcutol (X3, 40–60%). The mixture experimental design proposed twenty-three formulations with varying omega-3 SNEDDS formulation component percentages. The optimized omega-3 SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized omega-3-SNEDDS achieved significant improvement in the gastric ulcer index in comparison with pure omega-3 oil. Histopathological findings confirmed the protective effect of the formulated optimized omega-3 SNEDDS in comparison with omega-3 oil. These findings suggest that formulation of omega-3 in the form of a SNEDDS would be more effective in gastric ulcer protection than the administration of omega-3 as a crude oil.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

et al. 2020

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“…Proton pump inhibitors (PPIs), which were introduced in the 1980s, are regularly applied to reduce gastric acidity. Some patients with peptic ulcer, gastroesophageal reflux disease, dyspepsia, Hp eradication, and so forth are required to receive different course (2–8 weeks) of PPI therapy . Other patients exposed to anticoagulation drugs (aspirin, warfarin, etc.)…”

Section: Introductionmentioning

confidence: 99%

Relationship between long‐term use of proton pump inhibitors and risk of gastric cancer: A systematic analysis

Jiang

Wen

et al. 2019

J of Gastro and Hepatol

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Background and Aim:This study aims to systematically analyze the effect of long-term therapy with proton pump inhibitors (PPIs) on the risk of gastric cancer. Methods: PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China biomedical literature database (CBM) were searched for studies before February 2019. We evaluated the quality of the included articles through the Newcastle-Ottawa Scale and gathered relevant data to calculate the pooled odds ratio (OR) through Stata14.0. Results: Seven relevant articles conformed to the inclusion criteria; 943 070 patients were included. The pooled OR was 2.50; 95% CI (1.74, 3.85); the subgroup analysis results showed that patients who had used PPIs for more than 36 months were most likely to develop gastric cancer, and an increased risk was observed among patients after Helicobacter pylori eradication. Noncardia gastric cancer was more likely to develop. Conclusions: Long-term use of PPIs can possibly increase the risk of gastric cancer even among patients after H. pylori eradication; in particular, for noncardia gastric cancer, the risk increases with longer durations of PPI use. Due to the limited number of studies, more high-quality studies are required to be designed. 7After H. pylori eradication H2RA, histamine 2 receptor antagonist; PPIs, proton pump inhibitors.

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“…Your doctor will most likely recommend a biopsy of a gastric ulcer before beginning treatment. The biopsy will make sure there is no cancer hiding in the ulcer (Kuna et al, 2019).…”

Section: Types Of Peptic Ulcermentioning

confidence: 99%

“…Conventional treatments of peptic ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in the prevention and treatment of peptic ulcer (Kuna et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

An Overview on the Healing Potentials of Musa sapientm (Banana) in the Treatment of Peptic Ulcer Disease

Isah¹,

Abdulkadir²,

Raubilu³

et al. 2019

UJMR

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Gastric ulcer is a localized area of erosion in the stomach lining, resulting in abdominal pain, possible bleeding, and other gastrointestinal symptoms. The most common cause of gastric ulcer is Non-steroidal anti-inflammatory drugs (NSAIDs) and a stomach infection associated with the Helicobacter pylori (H. pylori) bacteria. The management of peptic ulcer disease and its complications remain a surgical challenge. Therefore, the evolution of newly discovered antiulcer drugs from medicinal plant is an attractive area, because several chemicals with anti-ulcer effect have been found in these plants, and they have shown a promising potential in the treatment of disease. Musa sapientum (Family: Musaceae), known as banana, is a familiar tropical fruit, is a treelike perennial herb that grows 5-9 m in height, with tuberous rhizome, hard, long pseudo-stem. The inflorescence is big with a reddish-brown bract, and it is eaten as vegetables, and the ripe fruits are sweet. Some studies reported that pectin and phosphatidylcholine in green banana strengthens the mucous-phospholipid layer that protects the gastric mucosa. Other studies highlight reported that leucocyanidin, a natural flavonoid from the unripe banana (Musa sapientum) pulp, protects the gastric mucosa from erosions.The present study is aim at reviewing the relevant studies on bioactive compounds in Musa sapientmwith their healing potentials in gastric ulcer diseases.

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Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options

Cited by 248 publications

References 105 publications

RETRACTED: Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

RETRACTED: Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

Relationship between long‐term use of proton pump inhibitors and risk of gastric cancer: A systematic analysis

An Overview on the Healing Potentials of Musa sapientm (Banana) in the Treatment of Peptic Ulcer Disease

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