Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine

Farzaei, Mohammad Hosein; Shahpiri, Zahra; Mehri, Mohammad Reza; Bahramsoltani, Roodabeh; Rezaei, Mahdi; Raeesdana, Azade; Rahimi, Roja

doi:10.2174/1389200219666180305150256

Cited by 21 publications

(12 citation statements)

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“…DPPH and ABTS assays have been commonly used to determine the free radical scavenging activity of plant extracts and their pure compounds (Reddy et al, 2003;Farzaei et al, 2018). Based on the free radical scavenging results, red hulls of P. vera L. were found to have the most significant antioxidant potentials than the other parts of the plant, which may be due to the fact that its rich secondary metabolites components such as epicatechin, quercetin, naringenin, luteolin, kaempferol,cyanidin-3-O-galactoside and cyanidin-3-O-glucoside (Bozorgi et al, 2013;Seifaddinipour et al, 2018).…”

Section: Results and Discussion Free Radical Scavenging Activitymentioning

confidence: 99%

“…Recently, dietary medicinal plants have been gained a great interest to reduce Reactive Oxygen Species (ROS) including hydroxyl radical (OH), hydrogen peroxide (H 2 O 2 ) and superoxide ion (O 2 ) formation, occurring naturally in the human body. In living organisms, preventing the side effects of ROS is one of the most effective management strategy for oxidative-stress related diseases including cancer, cardiovascular disease, chronic kidney diseases, aging, diabetes, rheumatoid arthritis atherosclerosis, and neurodegenerative diseases (Reddy et al, 2003;Schieber and Chandel, 2014;Farzaei et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Gezici¹

2019

International Journal of Agriculture Environment and Food Sciences

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This research was performed to assess cancer prevention and neuroprotective capacities of different parts of Pistachio (Pistachio vera L.). Red hulls, kernels and oleo-gum resins of Pistachio were extracted with methanol-MeOH and distilled water-dH 2 O, and subjected to in vitro biological assays varying from 100 to 1000 μg mL −1 concentrations. Their anticancer activities were evaluated against A549, MCF-7, and HeLa human cancer cells. Neuroprotective activities of the extracts were tested through enzyme inhibition on AChE, BChE, and TYR, which are closely related to pathogenesis of neurobiological disorders, particularly Alzheimer's and Parkinson's diseases. Due to cancer and neurodegenerative diseases are associated with oxidative damage, the extracts were analyzed for their antioxidant activities. With respect to free radical scavenging activities of the extracts, red hull extracts were found as the most potent ones both DPPH (67.95±1.13 to 80.55±0.12%) and ABTS (86.92±0.10 to 92.04±1.06%) radicals. The highest anticancer activity were determined in MeOH and dH 2 O extracts obtained from oleo-gum resin against HeLa cells (IC 50 = 18.50±0.85 and 28.97±0.08 µg mL-1 , p< 0.01, respectively), whilst dH 2 O-kernel extract was found to have the weakest anticancer activity towards A549 cells (IC 50 = 268.66±1.02 µg mL-1 , p< 0.01). Neuroprotective potentials on AChE and BChE enzymes were resulted in the superiority of dH 2 O-red hull extract was exerted the highest inhibition on AChE and BChE enzymes with 81.50±0.08 and 62.96±1.01% inhibition, respectively. However, dH 2 O extract from oleo-gum resin showed the highest inhibitory effect on TYR enzyme (58.16±0.18% inhibition). P. vera is of valuable nutritional source for human diet. Other than kernel parts used as food, waste parts like red hulls and oleo-gum resins have been proven as a potential pharmacological source. Consequently, this study reveals that non-food parts of Pistachio could be valuable source for pharmaceutical industry.

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Section: Results and Discussion Free Radical Scavenging Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Gezici¹

2019

International Journal of Agriculture Environment and Food Sciences

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“…Various pharmacological agents have been studied and used to find suitable therapeutic interventions in neurodegenerative diseases; however, some defects have always been associated with such treatments, since the pathophysiology of such impairments is yet to be elucidated. A wide range of phytopharmaceuticals are being explored to improve the effects of commonly used drugs in the treatment of neurogenic disorders (Farzaei et al, 2018a), both via prophylactic and disease controlling approaches (Gorji et al, 2018). Natural products can also provide templates for the development of other drug compounds and to design new effective complex molecules (Babitha et al, 2014).…”

Section: Polyphenols In Neurodegenerative Disordersmentioning

confidence: 99%

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

et al. 2020

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Polyphenols can act as proteasome-inhibitors or may modulate the proteasome activity, thereby improving neurodegenerative disorders by means of accumulation of ubiquitinated proteins, suppression of neuronal apoptosis, reduction of neurotoxicity, and improvement of synaptic plasticity and transmission. HIGHLIGHTS • Aberrant accumulation of intracellular ubiquitin-positive inclusions associated to neurodegenerative disorders. • Polyphenols, can act as proteasome-inhibitors or may modulate the proteasome activity. • Polyphenols can manage neurodegenerative impairments by targeting the ubiquitin-proteasome system (UPS). • Polyphenols exert UPS inhibitory activity, resulting in the accumulation of ubiquitinated proteins, suppression of neuronal apoptosis, reduction of neurotoxicity, and improvement of synaptic plasticity and transmission.

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“…Moreover, TCM was shown to improve the symptoms of cognitive and behavioral impairments in AD subjects . Medicinal plants used in traditional Persian medicine have also shown notable advantages for NDs treatment (Farzaei et al, 2018b). In another study, a balanced based exercise regimen was shown to improve the postural stability in PD patients (Li et al, 2012).…”

Section: Clinical Strategies Management Challenges and Limitations mentioning

confidence: 99%

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Moradi

Momtaz

Bayrami

et al. 2020

Front. Bioeng. Biotechnol.

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Nanotechnology is one of the methods that influenced human life in different ways and is a substantial approach that assists to overcome the multiple limitations of various diseases, particularly neurodegenerative disorders (NDs). Diverse nanostructures such as polymer nanoparticles, lipid nanoparticles, nanoliposomes, nano-micelles, and carbon nanotubes (CNTs); as well as different vehicle systems including poly lacticco-glycolic acid, lactoferrin, and polybutylcyanoacrylate could significantly increase the effectiveness, reduce the side effects, enhance the stability, and improve the pharmacokinetics of many drugs. NDs belong to a group of annoying and debilitating diseases that involve millions of people worldwide. Previous studies revealed that several nanoformulations from a number of natural products such as curcumin (Cur), quercetin (QC), resveratrol (RSV), piperine (PIP), Ginkgo biloba, and Nigella sativa significantly improved the condition of patients diagnosed with NDs. Drug delivery to the central nervous system (CNS) has several limitations, in which the blood brain barrier (BBB) is the main drawback for treatment of NDs. This review discusses the effects of herbalbased nanoformulations, their advantages and disadvantages, to manage NDs. In summary, we conclude that herbal-based nano systems have promising proficiency in treatment of NDs, either alone or in combination with other drugs.

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Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine

Cited by 21 publications

References 0 publications

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

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