Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense

Abstract

In traditional medicine Gossypium barbadense L. is used against hypertension. Looking for a scientific basis for this use, the blood-pressure-lowering effect of the decoction of the leaves was confirmed. Fraction II (frII) of the crude extract of G. barbadense showed a dose-dependent hypotensive effect in anaesthetized rats. In hexamethonium-treated rats, the blood-pressure-lowering effect of frII was almost abolished. A small decrease of the blood-pressure-lowering effect was followed by an increase in the blood pressure. Phentolamine antagonized the increase in blood pressure in hexamethoniumtreated rats. High doses of atropine (4 mg/rat) suppressed both depressor and heart effects. In-vitro experiments revealed that atropine did not antagonize the contraction of the ileum of the rat. Tripelennamine in a concentration of 100 microg could not influence the contraction either, whereas 300 microg did. In the guinea-pig ileum 10 microg tripelennamine did not reduce the contraction significantly. In the mechanism of action of frII, acetylcholine receptors could be involved, but not histaminergic or adrenergic receptors. Although it is still not known which compound(s) in G. barbadense is (are) the active substance(s), the results obtained may explain the use of this plant in traditional medicine in Suriname.

Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil

“…To the best of our knowledge, there are no studies on the anti-inflammatory effect of Gossypium barbardense on the uterine or other animal models of inflammation, nor are there any studies that addressed its use in the treating or managing of women's ailments mentioned in this study, thereby constituting a potential prospect for future studies. The only confirmed pharmacological effect was on the blood-pressure-lowering effect of its leaves decoction (Hasrat et al, 2004). It will be interesting therefore, to carry out test using experimental models to verify the ethnomedicinal use of the plant.…”

Effect on blood pressure of a dietary supplement containing traditional medicinal plants of Côte d’Ivoire

“…Our results show that the total aqueous extract of the traditional dietary supplement for hypertensive patients (abbreviated TDSHP as well as its total aqueous extract) from 5 × 10 −8 to 5 × 10 −2 mg/kg bw, has a dose-dependent hypotensive effects in rabbits, similar to extracts from many medicinal plants such as Mareya micrantha (Euphorbiaceae) (Abo et al, 2000), Bambusa vulgaris (Poaceae) (N'guessan et al, 2009), Anarcadium occidentale (Anacardiaceae) (Tchikaya et al, 2003), Gossypium barbadense (Malvaceae) (Hasrat et al, 2004) Hibiscus sabdariffa (Malvaceae) (Mojiminiyi et al, 2007). The decrease in blood pressure induced by TDSHP is similar to that caused by ACh.…”

Effet antihypertensif de BpF2, une fraction d\'extrait aqueux de feuilles de <i>Bidens pilosa</i> L. (Asteraceae) chez le lapin

“…Ces mêmes études indiquent que BpF 2 , de 1 à 25 mg/kg de P.C., a des effets hypotenseurs dose dépendante chez le lapin, semblables à ceux des extraits de nombreuses plantes médicinales telles que Mareya micrantha (Abo, 1996;Abo et al, 2000), Daucus carota (Gilani et al,2000), Swartzia madagascariencis (Soro et al, 2004), Heliotropium indicum (Traoré et al, 2002) et Gossypium barbadense (Hasrat et al,2004). Ces résultats sont conformes aux études de Dimo et al (1999) qui ont montré que l'extrait méthanolique des feuilles de Bidens pilosa L. induisait un effet hypotenseur qui est plus significatif chez les rats spontanément hypertendus, que chez les rats hypertendus par surcharge de sel et les rats normotendus.…”