Medicinal plants in the Balkans with antimicrobial properties

Shabih, Sarah; Hajdari, Avni; Mustafa, Behxhet; Quave, Cassandra L.

doi:10.1016/b978-0-323-90999-0.00013-6

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…The cultures were incubated at 25 °C for 72 h. The MIC of ERF was defined as the lowest concentration that effectively suppressed fungal growth. DMSO was used as a negative control [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities

et al. 2022

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Flowers are rich sources of bioactive antimicrobial, antioxidant, and anticancer components. This study aimed to determine the constituents of the ethanol extract of Malvaviscus arboreus red flower (ERF) by GC-MS analysis and HPLC identification of phenolic compounds and flavonoids, in addition to the 1HNMR fingerprint. The antimicrobial, antioxidant, and cytotoxic activities of the ERF were investigated. The GC-MS analysis revealed twenty-one components, while HPLC analysis revealed the presence of phenolic and flavonoid compounds. The ERF showed antifungal and antibacterial activity. The highest antibacterial activity was found against Vibrio damsela where a time-kill assay revealed a decline in the amount of viable V. damsela. For fungi, the highest activity was observed against Aspergillus terreus. Using the SRB test on HepG2, the anti-proliferative efficacy of the ERF was evaluated. Cell cycle analysis was utilized to determine autophagic cell death. The ERF prevented the proliferation of the HepG2 cell line with an IC50 of 67.182 µg/µL. The extract primarily promoted apoptosis in HepG2 cells by accumulating hypodiploid cells in the sub-G0/G1 phase, increased caspase 3/7 activity, and caused considerable autophagic cell death in apoptosis-deficient cells. Finally, the observed elevation of cancer cell death indicated that ERF had substantial anticancer potential against HepG2 cells.

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Section: Methodsmentioning

confidence: 99%

Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities

et al. 2022

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“…Peppermint (Mentha x piperita L.) represents a well-known aromatic and medicinal herb derived from crossing between spearmint (Mentha spicata L.) and water mint (Mentha aquatica L.). It belongs to the Lamiaceae family and is native to the Mediterranean region but is now cultivated in various parts of the world (34). Peppermint is one of the most important plant species in the pharmaceutical and cosmetic industries, whose EO is widely produced and used.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo anthelmintic efficacy of peppermint (Mentha x piperita L.) essential oil against gastrointestinal nematodes of sheep

Štrbac,

Krnjajić,

Stojanović

et al. 2023

Front. Vet. Sci.

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Nowadays, the exclusive use of commercial anthelmintics for the treatment of gastrointestinal nematode infections in ruminants is less sustainable due to anthelmintic resistance, as well as the problem of drug residues in animal products and the environment. Therefore, an integrated therapeutic approach is needed, including the search for alternatives to synthetic anthelmintic drugs. The aim of this study was to evaluate the possibility of using the essential oil of peppermint (Mentha x piperita L.) in the control of gastrointestinal nematodes in sheep. For this purpose, the in vitro and in vivo anthelmintic efficacy of this oil and the toxic effects on the hosts were examined. In the in vitro egg hatch test, ovicidal activity varied from 21.0–90.3% depending on the concentration of essential oil used (0.0125, 0.025, 0.049, 0.195, 0.781, 3.125, 12.5, and 50 mg/mL). To some extent, anthelmintic efficacy was confirmed in the in vivo fecal egg count reduction test at a mean dose of 150 mg/kg, with an average reduction of nematode eggs of 26.9 and 46.0% at Days 7 and 14 after treatment, respectively. Furthermore, no toxic effects of applied oil were observed on sheep behavior, kidney, or liver function. The main compounds identified by gas chromatography–mass spectrometry analyzes were menthol (32.6%), menthone (22.0%), menthyl-acetate (10.0%), and isomenthone (9.39%). Due to their complex chemical compositions, numerous bioactive ingredients, and natural origin, herbal formulations represent a potentially valuable alternative for the control of gastrointestinal nematodes in sheep. In this context, the results of the present study showed that peppermint essential oil is one of the promising candidates. Further studies should be performed to collect more data on the safety profile of M. piperita EO in treated animals to find the most appropriate formulation for use in field conditions and to test it against resistant gastrointestinal nematode populations.

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Individual and combined effect of different growing media on growth and establishment of new Indian oregano (Origanum vulgare L.)

Kumar,

Khan,

Tiwari

et al. 2024

JMAPS

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Owing to its medicinal attributes and appealing taste, the market for oregano is steadily increasing worldwide. Consequently, there is an immense need to enhance its production to meet this growing demand. For plant cultivation, a suitable growth medium is essential as it serves as a source and sink for essential nutrients required for plant growth and development. Recognizing the importance of boosting oregano production, an experiment was conducted to unveil the individual and combined performance of various growth media, namely soil, vermicompost, rooting hormone, and cocopeat. The findings of the experiment revealed that all the growth media effectively supported the plant’s growth and establishment by providing necessary nutrients. However, it was observed that a combination of vermicompost and rooting hormone had a particularly significant positive impact on various agronomical attributes. This combination resulted in enhanced root and shoot growth, indicating that vermicompost primarily promotes the development of roots, shoots, and leaves while rooting hormone positively influences root weight and overall plant development. As a result, this combination contributed to the establishment and growth of oregano seedlings. By implementing these findings, farmers can enhance the production of oregano, meeting the rising demand and ensuring a sustainable supply of this valuable herb. Keywords: Oregano, Soil, Vermicompost, Rooting hormone, Cocopeat.

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Medicinal plants in the Balkans with antimicrobial properties

Cited by 3 publications

References 64 publications

Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities

Phytochemical Profile of the Ethanol Extract of Malvaviscus arboreus Red Flower and Investigation of the Antioxidant, Antimicrobial, and Cytotoxic Activities

In vitro and in vivo anthelmintic efficacy of peppermint (Mentha x piperita L.) essential oil against gastrointestinal nematodes of sheep

Individual and combined effect of different growing media on growth and establishment of new Indian oregano (Origanum vulgare L.)

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