Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach

Albuquerque, Ulysses Paulino; Medeiros, Patrícia Muniz de; Almeida, Alyson Luiz Santos de; Monteiro, Júlio Marcelino; Neto, Ernani Machado de Freitas Lins; Melo, Joabe Gomes de; Santos, João Paulo de Oliveira

doi:10.1016/j.jep.2007.08.017

Cited by 593 publications

(373 citation statements)

References 67 publications

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“…Tel: +55 81 2126-8511; Fax: +55 812126-8510 material for the development of antifungal drugs (Cruz et al, 2007;Souza et al, 2010). Although the number of reports on species distributed by regions or biomes remains relatively small, interest in medicinal plants from northeastern Brazil has been increasing, especially in plants from the semi-arid Caatinga biome (Albuquerque et al, 2007a). Several studies have described this region's rich diversity of plants used for medicinal purposes, widely employed by the traditional communities until the present day (Almeida et al, 2005;Albuquerque et al, 2007a,b;Agra et al, 2007Agra et al, , 2008Cruz et al, 2007;Silva et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of medicinal plants from Northeastern Brazil

Ferreira¹,

Santiago²,

Langassner³

et al. 2013

J. Med. Plants Res.

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The aim of this work was to find how medicinal plants play an important role as source of new bioactive molecules. To evaluate the antifungal activity of 10 medicinal plants from northeastern Brazil, traditionally used as anti-infective agents. The activity of 30 crude extracts (water; ethanol:water, 1:1; acetone:water, 1:1) against four standard species of Candida yeasts (Candida albicans ATCC 90028, Candida dubliniensis ATCC 7289, Candida glabrata ATCC 2001 and Candida krusei ATCC 6258) was investigated by the Minimal Inhibitory Concentration (MIC), using the microdilution method and the working range used was from 1.95 to 1000 μg/mL. Extracts from leaves of Eugenia uniflora (Myrtaceae), stem bark of Caesalpinia ferrea (Caesalpinaceae) and leaves of Psidium guajava (Myrtaceae) showed significant activity against all yeasts evaluated. The best antifungal activities were achieved against C. glabrata and C. krusei by E. uniflora extract (MIC = 15.62) and followed by extracts from C. ferrea and P. guajava (MIC ranged from 15.62 to 250 µg/mL). E. uniflora also showed fungicidal properties against all yeasts, especially against Candida dubliniensis. This study identified plant species that may be candidates for the development of alternative treatments for candidiasis.

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Section: Introductionmentioning

confidence: 99%

Antifungal activity of medicinal plants from Northeastern Brazil

Ferreira¹,

Santiago²,

Langassner³

et al. 2013

J. Med. Plants Res.

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“…Of the plant species that have been documented as having medicinal effects against helminths, Lantana camara, Tagetes minuta (ALBUQUERQUE et al, 2007), Alpinia zerumbet (ALMEIDA, 1993) and Coriandrum sativum (HUSSAIN et al, 2008) are commonly cited.…”

Section: Introductionmentioning

confidence: 99%

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Macedo

Oliveira

Camurça-Vasconcelos

et al. 2013

Rev. Bras. Parasitol. Vet.

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In vitro effects of AbstractPhytotherapy can be an alternative for the control of gastrointestinal parasites of small ruminants. This study evaluated the efficacy of Alpinia zerumbet, Coriandrum sativum, Tagetes minuta and Lantana camara essential oils by two in vitro assays on Haemonchus contortus, an egg hatch test (EHT) and larval development test (LDT). No effect was observed for L. camara in the EHT. A. zerumbet, C. sativum and T. minuta essential oils exhibited a dose-dependent effect in the EHT, inhibiting 81.2, 99 and 98.1% of H. contortus larvae hatching, respectively, at a concentration of 2.5 mg mL -1 . The effective concentration to inhibit 50% (EC50) of egg hatching was 0.94, 0.63 and 0.53 mg mL -1 for A. zerumbet, C. sativum and T. minuta essential oils, respectively. In LDT, L. camara, A. zerumbet, C. sativum and T. minuta at concentration of 10 mg mL -1 inhibited 54.9, 94.2, 97.8 and 99.5% of H. contortus larval development, presenting EC50 values of 6.32, 3.88, 2.89 and 1.67 mg mL -1 , respectively. Based on the promising results presented in this in vitro model, it may be possible use of these essential oils to control gastrointestinal nematodes. However, their anthelmintic activity should be confirmed in vivo.Keywords: Phytotherapy, anthelmintic, gastrointestinal nematodes. ResumoFitoterapia pode ser uma alternativa para o controle de parasitas gastrintestinais de pequenos ruminantes. Este estudo avaliou a eficácia dos óleos essenciais de Alpinia zerumbet, Coriandrum sativum, Tagetes minuta e Lantana camara sobre Haemonchus contortus através de dois testes in vitro, teste de eclosão dos ovos (TEO) e teste de desenvolvimento larval (TDL). Nenhum efeito foi observado para L. camara no TEO. Os óleos essenciais de A. zerumbet, C. sativum e T. minuta exibiram um efeito dose dependente no TEO inibindo a eclosão das larvas de H. contortus em 81,2, 99 e 98,1%, respectivamente, na concentração de 2,5 mg mL -1 . A concentração efetiva para inibir 50% (CE50) da eclosão dos ovos foi de 0,94, 0,63 e 0,53 mg mL -1 para os óleos essenciais de A. zerumbet, C. sativum e T. minuta, respectivamente. No TDL, 10 mg mL -1 de L. camara, A. zerumbet, C. sativum e T. minuta inibiram em 54,9, 94,2, 97,8 e 99,5% do desenvolvimento larvar, apresentando valores de CE50 de 6,32, 3,88, 2,89 e 1,67 mg mL -1 , respectivamente. Com base nos resultados promissores apresentados neste modelo in vitro, pode ser possível a utilização destes óleos essenciais para controlar os nematoides gastrintestinais. No entanto, a sua atividade anti-helmíntica deve ser confirmada in vivo.Palavras-chave: Fitoterapia, anti-helmínticos, nematoides gastrintestinais.

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“…Brazil not only has one of the world's highest levels of biodiversity but also it has a wealth of traditional knowledge accumulated by local people who have direct access to nature and to the products of biodiversity (Albuquerque et al, 2007). In this sense, information from Brazilian ethnic groups on traditional medicine have contributed to the discovery of pharmacological activities from several plant-derived agents, which have resulted in a signifi cant body of publications (Almeida et al, 2001;Sousa et al, 2004a;2005;De Sousa et al, 2006;Amaral et al, 2007;Silva et al, 2007;Volpato et al, 2008;Silva et al, 2009a;Silva et al 2009b;Morais at al., 2010).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach

Cited by 593 publications

References 67 publications

Antifungal activity of medicinal plants from Northeastern Brazil

Antifungal activity of medicinal plants from Northeastern Brazil

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

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