Medicinal plants possessed beneficial therapeutic effects in Alzheimer’s disease and memory deficits

Abstract

Alzheimer's disease is the most common cause of dementia, accounting for an estimated 60% to 80% of cases. The treatment of Alzheimer's disease remains challenging. Many medicinal plants possessed beneficial therapeutic effect inAlzheimer’s disease and memory deficits, by their anti-inflammatory, antioxidant, neuroprotective, NF-κB inhibition, phosphodiesterase inhibition, anti-amyloidogenic, and anticholinesterase activities. In the current article, the medicinal plants with beneficial effects in Alzheimer’s disease and memory deficits were discussed. This article considers not only the therapeutic effect of medicinal plants in AD and memory deficits, but also discussed the mechanisms of their beneficial effects.

Medicinal plants with cholinesterase inhibitory activity and their applications

“…Some of reversible and irreversible AChE inhibitors were applied in pharmacology in Alzheimer's disease, Parkinson's disease, myasthenia gravis and glaucoma (2) . Many previous pharmacological studies revealed that the medicinal plants possessed cholinesterase inhibitory effects and were tested in Alzheimer's disease and memory deficits and as anti-Parkinsonian (4)(5)(6)(7)(8) .…”