Medicinal plants with antidiabetic effects (part 2): plant based review

Al-Snafi, Prof Dr Ali Esmail

doi:10.9790/3013-06724961

Cited by 21 publications

(26 citation statements)

References 43 publications

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“…Fruits of the Mission variety contained the highest levels of polyphenols, flavonoids, and anthocyanins and exhibited the highest antioxidant capacity [70].Six organic acids were identified in the fig leaves including: oxalic, citric, malic, quinic, shikimic, and fumaric acids [69].Ficins, cysteine endoproteolytic proteases were isolated from Ficus carica latex, these included ficins A, B, C, D1, D2 and E [71][72].Many volatile compounds were isolated from Ficus carica fructus included 2,3-butane-diol, tetramethyl-decane, trimethylundecane, octadecane, carvacrol, ß-Caryophyllene, caryophyllene-oxid and apiol [68].The volatile profile of fresh fruits (pulp and peel) and leaves of Portuguese Ficus carica white (Pingo de Mel and Branca Tradicional) and dark (Borrasota Tradicional, Verbera Preta and Preta Tradicional) varieties revealed the presence of fifty-nine compounds including (aldehydes, alcohols, ketones, esters, monoterpenes, sesquiterpenes, norisoprenoids). The highest diversity of compounds was found in leaves (40), followed by pulps (30) and peels (27), Pulps and peels were distinguished from leaves by their abundance of monoterpenes and aldehydes. All varieties presented a similar volatile profile, although some differences between white and dark varieties were noticed.…”

Section: Ii-chemical Constituentsmentioning

confidence: 99%

Nutritional and pharmacological importance of Ficus carica - A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-The preliminary phytocemical analysis showed that the fruits of Ficus carica contained alkaloids, tannins, glycosides, flavanoids, saponins, coumarins, sterols, terpenes carbohydrates, phenols, essential oil, volatile oil, proteins and minerals. The previous pharmacological studies revealed that Ficus carica possessed antibacterial, antiviral, antiparasitic, antioxidant, anticancer, antimutagene, anti-angiogenic, antiinflammatory, antipyretic, antidiabetic, antiplatelet, reproductive, endocrine, immunological, dermatological, hypolipidemic, nootropic, antispasmodic, antidiarrheal, anti-warts, nephro-and hepato-protective effects. The current paper reviewed the chemical constituents, nutritional and pharmacological importance of Ficus carica.

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Section: Ii-chemical Constituentsmentioning

confidence: 99%

Nutritional and pharmacological importance of Ficus carica - A review

Al-Snafi¹

2017

IOSRPHR

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“…The Phytochemical analysis of Eucalyptus microtheca leaves extracts revealed the presence of essential oils, flavonoids, tannins and alkaloids [108]. The major components of Eucalyptus microtheca essential oils were 1,8-cineole (34.0%), p-cymene (12.4%), α-pinene (10.7%), β-pinene (10.5%) and virdiflorene (5.2%) [95].However, in the oil of Eucalyptus microtheca flowers, 88 compounds were identified including (%): α -thujene 0.504; α -pinene 16 …”

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confidence: 99%

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Al-Snafi¹

2017

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Abstract:-Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8-cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and ϒ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.

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“…A total of 24 male Wistar rats were divided into six groups: C− was the control group, C+ was rats with streptozotocin-induced diabetes, T1 was diabetic rats with fasting treatment for 12 h, T2 was diabetic rats with a diet of alginate nanofibers ad libitum , T3 was diabetic rats with metformin (400 mg/kg body weight [BW]/day peroral treatment [ 13 ]) and a diet of alginate nanofibers ad libitum , and T4 was diabetic rats with metformin (400 mg/kg BW/day). All groups were treated for 21 days.…”

Section: Methodsmentioning

confidence: 99%

Dietary polyvinyl alcohol and alginate nanofibers ameliorate hyperglycemia by reducing insulin and glucose-metabolizing enzyme levels in rats with streptozotocin-induced diabetes

et al. 2021

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Background and Aim: Dietary management and antidiabetic drugs are used as therapies for diabetic patients worldwide. Alginate nanofibers were developed as a digestible food product that provides sufficient calories. This study aimed to evaluate the effect of polyvinyl alcohol (PVA) and alginate nanofibers on weight gain, blood glucose levels, and insulin and other serum parameters in diabetic rats. Materials and Methods: A total of 24 male Wistar rats were divided into six groups: (C–) Control group, (C+) diabetic rats, (T1) diabetic rats + fasting treatment for 12 h, (T2) diabetic rats + nanofibers ad libitum, (T3) diabetic rats + metformin + nanofibers ad libitum, and (T4) diabetic rats + metformin. All groups were treated for 21 days. Weight gain was evaluated by comparing initial and final weights. Blood glucose levels were evaluated weekly. Serum parameters were also evaluated at the end of the study. All variables were analyzed statistically using analysis of variance followed by Tukey's post hoc test (p<0.05). Results: The T2, T3, and T4 groups showed a significant increase in weight compared to that of the C+ and T1 groups. The T3 group had the lowest blood glucose level of all groups at the end of the study. In the serum evaluation, the T2 and T3 groups showed a significant decrease compared to the C+ group for the following variables: Alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), creatinine, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β). In contrast, the T2 group showed a significant decrease compared to the T3 group for aspartate aminotransferase and insulin levels. Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-α, and IL-1β in diabetic rats.

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Medicinal plants with antidiabetic effects (part 2): plant based review

Cited by 21 publications

References 43 publications

Nutritional and pharmacological importance of Ficus carica - A review

Nutritional and pharmacological importance of Ficus carica - A review

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Dietary polyvinyl alcohol and alginate nanofibers ameliorate hyperglycemia by reducing insulin and glucose-metabolizing enzyme levels in rats with streptozotocin-induced diabetes

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