Medicinal plants with potential antidiabetic activity - A review of ten years of herbal medicine research (1990-2000)

Bnouham, Mohamed; Ziyyat, Abderrahim; Mekhfi, Hassane; Tahri, Abdelhafid; Legssyer, Abdelkhaleq

doi:10.1159/000497588

Cited by 268 publications

(156 citation statements)

References 149 publications

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“…19 In the present study, the dysregulation of glucose metabolism observed in STZ-diabetic rats was overcome following treatment with either the PRF-Th or glibenclamide, which is an oral sulfonylurea antidiabetic preparation widely used as a reference drug in tests of antidiabetic activity. 20 Moreover, in the present study, PRF-Th significantly decreased systolic arterial pressure similar to the effects observed for captopril. Captopril is an angiotensin-converting enzyme inhibitor that blocks the conversion of the prohormone angiotensin I to the active hormone angiotensin II.…”

Section: Discussionsupporting

confidence: 87%

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats

Bnouham

Benalla

Bellahcen

et al. 2012

Journal of Diabetes

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Background: The present study examined the effect of the polyphenol-rich fraction from Thymelaea hirsuta (PRF-Th) in a rat model of streptozotocin (STZ)-diabetes and nitric oxide (NO)-deficient hypertension. Methods: Diabetes was induced by a single dose of STZ (90 mg ⁄ kg, i.p.). To induce NO-deficient hypertension, rats were treated with the NO synthase inhibitor N G -nitro-l-arginine methyl ester; l-NAME; 30 mg ⁄ kg per day, p.o. for 3 weeks. The effects of 21 days treatment with 80 mg ⁄ kg per day PRF-Th in the drinking water were evaluated in diabetic-hypertensive (DH) rats. In all groups (n = 6 in each), glycemia and systolic blood pressure were determined weekly. At the end of the experiment, hepatic glycogen was determined. Results: Blood glucose levels decreased gradually from baseline until the end of the experiment in untreated DH rats (from 1.92 ± 0.09 to 1.3 ± 0.1 g ⁄ L; P < 0.05). Administration of PRF-Th concomitantly with l-NAME prevented the blood pressure increase in rats. After 21 days, blood pressure in PRF-Th + l-NAME-and l-NAME-treated rats was 132 ± 1 and 157 ± 1 mmHg, respectively (P < 0.001). Administration of 2 mL ⁄ kg per day PRF-Th to DH rats significantly increased hepatic glycogen levels compared with levels in untreated DH rats (13.65 ± 1.84 vs 6.34 ± 0.75 mg ⁄ g tissue, respectively; P < 0.01). Moreover, PRF-Th significantly reduced the amount of glucose absorbed in in situ perfused jejunum segments compared with control (by 33.6%; P < 0.001). This effect of PRF-Th was comparable with that of acarbose, an a-glucosidase inhibitor. Conclusions: The findings of the present study indicate that T. hirsuta has antidiabetic and antihypertensive activity in STZ-diabetic, NO-deficient hypertensive rats. This effect seems to be due to its rich polyphenol content. Therefore, T. hirsuta may be useful as a food supplement for the prevention of type 2 diabetes and hypertension.

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Section: Discussionsupporting

confidence: 87%

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats

Bnouham

Benalla

Bellahcen

et al. 2012

Journal of Diabetes

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“…Sitosterol-d-glucoside present in the bark of Ficus religiosa is believed to elicit hypoglycemic activity in rabbits [14]. The bioactive components present in Ficus are leucocyandin 3-O-beta-d-galactosyl cellobioside, leucopelargonidin-3-O-alpha-L rhamnoside [15, 16]. The phytoconstituents present in Ficus can impart a significant antidiabetic effect.…”

Section: Indian Medicinal Plants With Antidiabetic Potentialmentioning

confidence: 99%

Traditional Indian Medicines Used for the Management of Diabetes Mellitus

Rizvi

Mishra

2013

Journal of Diabetes Research

117

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Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show antidiabetic potential. The present review is aimed at providing in-depth information about the antidiabetic potential and bioactive compounds present in Ficus religiosa, Pterocarpus marsupium, Gymnema sylvestre, Allium sativum, Eugenia jambolana, Momordica charantia, and Trigonella foenum-graecum. The review provides a starting point for future studies aimed at isolation, purification, and characterization of bioactive antidiabetic compounds present in these plants.

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“…For long time, plants were used in treatment of many diseases especially in the East region countries [13]. In addition, Lycium barbarum protects mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation by reducing the hepatic necrosis and the serum alanine aminotransferase (ALT) level induced by CCl4 intoxication, inhibiting cytochrome P450 2E1 expression, and restoring the expression levels of antioxidant enzymes and decreasing the level of nitric oxide metabolism and lipid peroxidation induced by CCl4 [14].…”

Section: Introductionmentioning

confidence: 99%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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BackgroundLiver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 induced liver damage in male rats.MethodsForty males of a new model of albino rats (Wistar strain) (175–205 g) were divided into four groups. The 1st Group (G1) was the negative control group, the remaining rats were injected with CCl4 (1 ml/kg body weight) with equal amount of olive oil on the 1st and 4th day of every week for 4 weeks. The 2nd group (G2) was the positive control, the 3rd group (G3) and the fourth group (G4) were treated orally with N. sativa oil and olive oils using stomach tube.ResultsThe positive control group showed an increase in hepatic enzymes, total bilirubin, creatinine, uric acid, lipid peroxide total cholesterol, triglyceride, low density lipoprotein, very low density lipoproteins, interleukin-6, and a decrease in antioxidant enzymes, high density lipoprotein cholesterol, a decrease in total protein and albumin an when compared with negative control group. Histology of the CCl4 treated group revealed inflammation and damage of liver cells. Treating the hepatotoxic rats with olive oil and N. sativa oil showed a significant improvement in all biochemical tests compared with the positive CCl4 control group. In addition, the liver tissues of olive oil treated group showed mild improvement in inflammatory infiltration and in N. sativa oil treated group showed normal hepatocytes with no evidence of inflammation.ConclusionThis study revealed that olive oil and N. sativa oil have a protective effect against CCl4-induced hepatotoxicity in male rats. Nigella sativa oil was more effective than olive oil.

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Medicinal plants with potential antidiabetic activity - A review of ten years of herbal medicine research (1990-2000)

Cited by 268 publications

References 149 publications

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats

Traditional Indian Medicines Used for the Management of Diabetes Mellitus

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

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Medicinal plants with potential antidiabetic activity - A review of ten years of herbal medicine research (1990-2000)

Cited by 268 publications

References 149 publications

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and NG‐nitro‐l‐arginine methyl ester‐hypertensive rats

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and NG‐nitro‐l‐arginine methyl ester‐hypertensive rats

Traditional Indian Medicines Used for the Management of Diabetes Mellitus

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

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Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats

Antidiabetic and antihypertensive effect of a polyphenol‐rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin‐diabetic and N^G‐nitro‐l‐arginine methyl ester‐hypertensive rats