Medicinal Properties of &lt;i&gt;Clinacanthus nutans&lt;/i&gt;: A review

Yeo, Bann Siang; Yap, Yiing Jye; Koh, Rhun Yian; Ng, Khuen Yen; Chye, Soi Moi

doi:10.4314/tjpr.v17i2.25

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…Clinacanthus nutans is a medicinal plant that has many medicinal properties, including treating lesions generated by the herpes-simplex virus, antiinflammatory, anticancer, antibacterial, and antivenom activities [7]. C. nutans is found in Malaysia, Vietnam, Indonesia, Thailand, and China [8,9], and occurs in most habitats [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects, Antiproliferative Effects, and Molecular Docking of Clinacanthus nutans Leaf Extracts

et al. 2020

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Clinacanthus nutans is a well-known herb that has been used as an alternative and therapeutic medicine, however more selective C. nutans extracts are needed. In this study, leaves were extracted with 80% methanol and further fractionated with n-hexane, dichloromethane, chloroform, n-butanol, and aqueous residue. Subsequently, the total phenolic content (TPC), total flavonoid content (TFC), antioxidant scavenging activity, and antiproliferative effects on breast cancer (Michigan Cancer Foundation-7 [MCF7]) and normal breast (Michigan Cancer Foundation-10A [MCF 10A]) cells of the extracts were measured. Additionally, molecular docking simulation of the major compounds from C. nutans extracts was conducted. The aqueous residue had the highest TPC and TFC, whereas the crude extract had the highest scavenging activity. Among the extracts, dichloromethane extract (CN-Dcm) was selected as it had the highest selectivity index (SI) (1.48). Then, the chosen extract (CN-Dcm) was proceed for further analysis. The compounds from CN-Dcm were identified using gas chromatography–mass spectrometry (GC-MS). The major compounds from CN-Dcm were further investigated through molecular docking studies. Palmitic acid and linolenyl alcohol were the compounds found in the CN-Dcm extract that exhibited the highest binding affinities with p53-binding protein Mdm-2. These results highlight the potential of C. nutans as a source of anticancer activities.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Effects, Antiproliferative Effects, and Molecular Docking of Clinacanthus nutans Leaf Extracts

et al. 2020

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“…Both clinacosides showed anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced neurotoxicity in the in vivo rat model [9]. Furthermore, they displayed inhibitory effects towards human neutrophil elastase enzymes in silico, which indirectly signified their abilities to prevent inflammation in the respiratory system [13,52]. Based on their proven antioxidative and anti-inflammatory potentials, these three compounds are indeed promising hepatoprotective agents that warrant further investigations.…”

Section: Discussionmentioning

confidence: 99%

“…Based on their proven antioxidative and anti-inflammatory potentials, these three compounds are indeed promising hepatoprotective agents that warrant further investigations. Among the three compounds, isoschaftoside is the most stable phytochemical detected in C. nutans from different geographical locations, regardless of the environmental conditions [13]. Thus, it is deemed a suitable chemical marker to standardize C. nutans extract or even raw materials.…”

Section: Discussionmentioning

confidence: 99%

“…All these bioactivities are commonly reported in the polar and semi-polar extracts of C. nutans, which contain phytocompounds such as phenolics, flavonoids, sulfur-containing glucosides and phytosterols [12]. Variations of phytochemical levels are also observed in this plant species obtained from diverse geographical locations or cultivated in different environmental conditions [12,13]. In view of this, detailed information of the location where the herb is procured along with the date of harvest are provided by researchers to improve the reproducibility of results.…”

Section: Introductionmentioning

confidence: 91%

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Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

Tan²,

Bok³

et al. 2022

Molecules

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Antioxidants are currently utilized to prevent the occurrence of liver cancer in non-alcoholic fatty liver disease (NAFLD) patients. Clinacanthus nutans possesses anti-oxidative and anti-inflammatory properties that could be an ideal therapy for liver problems. The objective of this study is to determine the potential antioxidative compounds from the C. nutans leaves (CNL) and stems (CNS). Chemical- and cell-based antioxidative assays were utilized to evaluate the bioactivities of CNS and CNL. The NMR metabolomics approach assisted in the identification of contributing phytocompounds. Based on DPPH and ABTS radical scavenging activities, CNL demonstrated stronger radical scavenging potential as compared to CNS. The leaf extract also recorded slightly higher reducing power properties. A HepG2 cell model system was used to investigate the ROS reduction potential of these extracts. It was shown that cells treated with CNL and CNS reduced innate ROS levels as compared to untreated controls. Interestingly, cells pre-treated with both extracts were also able to decrease ROS levels in cells induced with oxidative stress. CNL was again the better antioxidant. According to multivariate data analysis of the 1H NMR results, the main metabolites postulated to contribute to the antioxidant and hepatoprotective abilities of leaves were clinacoside B, clinacoside C and isoschaftoside, which warrants further investigation.

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“…Moreover, a non-scientific and unpublished survey of ethnobotanical applications of medicinal plants has demonstrated that C. nutans rated amongst the top five most commonly used herbs for anti-diabetic, anti-hypertensive, anti-inflammatory and antioxidant properties in other sub-tropical countries such as in Malaysia, Brunei and Singapore. Other pharmacological activities such as anti-venom, anti-cancer, anti-bacterial, anti-fungal and anti-analgesic activities have also been reported [ 10 , 20 , 37 ].…”

Section: Pharmacological and Medicinal Propertiesmentioning

confidence: 99%

A Narrative Review on the Phytochemistry, Pharmacology and Therapeutic Potentials of Clinacanthus nutans (Burm. f.) Lindau Leaves as an Alternative Source of Future Medicine

et al. 2021

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The application of natural products and supplements has expanded tremendously over the past few decades. Clinacanthus nutans (C. nutans), which is affiliated to the Acanthaceae family, has recently caught the interest of researchers from the countries of subtropical Asia due to its medicinal uses in alternative treatment for skin infection conditions due to insect bites, microorganism infections and cancer, as well as for health well-being. A number of bioactive compounds from this plant’s extract, namely phenolic compounds, sulphur containing compounds, sulphur containing glycosides compounds, terpens-tripenoids, terpens-phytosterols and chlorophyll-related compounds possess high antioxidant activities. This literature search yielded about one hundred articles which were then further documented, including the valuable data and findings obtained from all accessible electronic searches and library databases. The promising pharmacological activities from C. nutans leaves extract, including antioxidant, anti-cancer, anti-viral, anti-bacterial, anti-fungal, anti-venom, analgesic and anti-nociceptive properties were meticulously dissected. Moreover, the authors also discuss a few of the pharmacological aspect of C. nutans leaves extracts against anti-hyperlipidemia, vasorelaxation and renoprotective activities, which are seldom available from the previously discussed review papers. From the aspect of toxicological studies, controversial findings have been reported in both in-vitro and in-vivo experiments. Thus, further investigations on their phytochemical compounds and their mode of action showing pharmacological activities are required to fully grasp both traditional usage and their suitability for future drugs development. Data related to therapeutic activity and the constituents of C. nutans leaves were searched by using the search engines Google scholar, PubMed, Scopus and Science Direct, and accepting literature reported between 2010 to present. On the whole, this review paper compiles all the available contemporary data from this subtropical herb on its phytochemistry and pharmacological activities with a view towards garnering further interest in exploring its use in cardiovascular and renal diseases.

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Medicinal Properties of <i>Clinacanthus nutans</i>: A review

Cited by 11 publications

References 7 publications

Antioxidant Effects, Antiproliferative Effects, and Molecular Docking of Clinacanthus nutans Leaf Extracts

Antioxidant Effects, Antiproliferative Effects, and Molecular Docking of Clinacanthus nutans Leaf Extracts

Metabolomic Approach for Rapid Identification of Antioxidants in Clinacanthus nutans Leaves with Liver Protective Potential

A Narrative Review on the Phytochemistry, Pharmacology and Therapeutic Potentials of Clinacanthus nutans (Burm. f.) Lindau Leaves as an Alternative Source of Future Medicine

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