Medicinal significance of naturally occurring cyclotetrapeptides

Abdalla, Muna Ali

doi:10.1007/s11418-016-1001-5

Cited by 33 publications

(21 citation statements)

References 89 publications

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“…Cyclic peptide nanoparticles and nanotubes have great potential for a wide range of biomedical applications [ 13 , 14 , 15 ]. Naturally occurring cyclic peptides have been isolated from plants [ 16 ], fungi [ 17 , 18 ], bacteria (including actinomycetes) [ 19 , 20 , 21 ], sponges [ 22 ], algae [ 23 , 24 ], and mammals [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

2018

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Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics and human peptide hormones. In this report, the importance of cyclic peptides is discussed, and their role in drug discovery as interesting therapeutic biomolecules will be highlighted. Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein.

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Section: Introductionmentioning

confidence: 99%

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

2018

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“…Moreover, numerous species of endophytic fungi have afforded a number of anticancer, antimicrobial, antidiabetic, insecticidal, and immunosuppressive compounds (Schneider et al, 2008 ). Interesting cyclotetrapeptides were isolated recently from endophytic fungi and bacteria (Abdalla, 2016 , 2017 ).…”

Section: Endophytes Are Potential Sources Of Secondary Metabolitesmentioning

confidence: 99%

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Abdalla

McGaw

2018

Front. Pharmacol.

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South Africa has a long history and strong belief in traditional herbal medicines. Using ethnobotanical knowledge as a lead, a large number of South African medicinal plants have been discovered to possess a wide spectrum of pharmacological properties. In this review, bioprospecting of endophytes is highlighted by following the advantages of the ethnomedicinal approach together with identifying unique medicinal plants where biological activity may be due to endophytes. This review focuses on the current status of South African medicinal plants to motivate the research community to harness the benefits of ethnobotanical knowledge to investigate the presence of endophytic microbes from the most potent South African medicinal plants. The potential chemical diversity and subsequent putative medicinal value of endophytes is deserving of further research. A timely and comprehensive review of literature on recently isolated endophytes and their metabolites was conducted. Worldwide literature from the last 2 years demonstrating the importance of ethnobotanical knowledge as a useful approach to discover endophytic microbes was documented. Information was obtained from scientific databases such as Pubmed, Scopus, Scirus, Google Scholar, Dictionary of Natural Products, Chemical Abstracts Services, official websites, and scientific databases on ethnomedicines. Primary sources such as books, reports, dissertations, and thesises were accessed where available. Recently published information on isolated endophytes with promising bioactivity and their bioactive natural products worldwide (2015-2017) was summarized. The potential value of South African medicinal plants as sources of endophytes is discussed. The insights provided through this study indicate that medicinal plants in South Africa are highly under-investigated sources of potentially useful endophytic microbes. New approaches may be used by medicinal plant scientists for further exploration of natural products from endophytic fungi and bacteria in southern Africa.

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“…[1][2][3][4][5][6] Therefore, the development of original cyclopeptide-based therapeutics is currently a growing interest. Some of them like the wellknown vancomycin and its derivatives, [6,7] gramicidin, [8,9] colistin, [10] octreotide, [11] and RGD (Arg-Gly-Asp) derivatives [12,13] exhibit useful biological properties as antibiotics, anticancer drugs and integrin inhibitors. Cyclic peptides also proved to be useful for the design of functional nanotubes from selfassembly.…”

Section: Introductionmentioning

confidence: 99%

Sugar γ‐Amino Acids as Building Blocks for the Synthesis of Cyclic Neoglycopeptides.

et al. 2018

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Anomeric sugar γ‐amino acids efficiently obtained by nucleophilic addition of nitronate anion on sugar olefins are useful building blocks for the preparation of new cyclic glycopeptides. Cyclopeptides have interesting biological properties or find potential applications as templates for anchoring of a wide range of biomolecules or detection dyes. We report here the synthesis of two types of cyclic systems containing γ‐glyco amino acid and α‐amino acid units. A first example was prepared to demonstrate the feasibility of the cyclization of these original structures. To explore the feasibility with more functionalized structures, α‐amino acid and sugar amino‐acid moieties bearing additional functions were chosen as building blocks for the second macrocycle. Furthermore, we describe and explain some unexpected results obtained during deprotection of these new cyclic glycopeptides.

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Medicinal significance of naturally occurring cyclotetrapeptides

Cited by 33 publications

References 89 publications

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes

Sugar γ‐Amino Acids as Building Blocks for the Synthesis of Cyclic Neoglycopeptides.

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