Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016

Golubnitschaja, Olga; Baban, Babak; Boniolo, Giovanni; Wei, Wang; Bubnov, Rostyslav; Kapalla, Marko; Krapfenbauer, Kurt; Mozaffari, Mahmood S.; Costigliola, Vincenzo

doi:10.1186/s13167-016-0072-4

Cited by 329 publications

(272 citation statements)

References 74 publications

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“…for this risk and, eventually, to prevention of adverse reactions by vaccination. It could represent a Bpersonalized medicine^that could potentially improve preventive methods and therapeutic options, accordingly with the recommendations of the BEuropean Association for Predictive, Preventive and Personalised Medicine^ [166]. …”

Section: Conclusion and Expert Recommendationsmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

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Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

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Section: Conclusion and Expert Recommendationsmentioning

confidence: 99%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

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“…In summary, here, we contribute to further understanding of biomarkers that can facilitate early diagnosis, prediction, classification/patient stratification, prognosis, and potentially treatment response, which could be used in clinical practice in line with follow-up steps in AD-dedicated research to satisfy patients' needs and to advance healthcare as elegantly outlined before for other diseases and for disease states in general [44].…”

Section: Expert Recommendations and Outlookmentioning

confidence: 93%

Specific protein biomarker patterns for Alzheimer’s disease: improved diagnostics in progress

Gozes

2017

EPMA Journal

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This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activitydependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor. This review will assess our data in comparison to selected independent studies focusing on blood protein biomarkers as well as assessing saliva and urine samples with potential predictive value for AD. Furthermore, the review will provide directions for a combination of innovative markers, stratifying the population toward disease prevention and personalized medicine.

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“…The number of people with obesity was projected doubled by 2025 [1]. Obesity and metabolic syndrome has been profoundly studied by experts of the European Association for Predictive, Preventive and Personalised Medicine (EPMA) [2][3][4][5][6][7], and effective solutions by predictive, preventive and personalized medicine (PPPM) were consequently suggested considering a sensitive balance between health and disease in individuals; environmental factors in epidemics and an interplay between a genetic component, epigenetic regulations, and environmental factors [4]. In Ukraine, more than a half of the adult population is overweight, which is certainly due to the low level of physical activity, eating behavior features, increase in diet-dense foods and carbohydrate and wide and uncontrolled use of food industry and online catering food additives, especially monosodium glutamate (MSG) [8].…”

Section: Overviewmentioning

confidence: 99%

Efficacy of nanoceria for periodontal tissues alteration in glutamate-induced obese rats—multidisciplinary considerations for personalized dentistry and prevention

et al. 2017

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Background Nowadays, we face the global epidemic of obesity, that is known to contribute to the development of many diseases, such as the oral cavity pathologies. Dental and oral pathologies are frequently caused by and overlapped with systemic multifactorial diseases such as obesity being its early indicators and risk factors.The aim was to study the influence of nanoceria on periodontal tissues alteration in glutamate (MSG)-induced obese rats. Methods We included 52 Wistar rats of both genders and divided into four groups: newborn rats in group 1 (control) received subcutaneously 8 μl/g saline. Group 2 received 3 to 4 mg/g MSG subcutaneously on the second, fourth, sixth, eighth, and tenth day of life; group 3-intragastric administration of nanocrystalline cerium dioxide at a dose of 1 mg/kg volume of 2.9 ml/kg against the background of glutamateinduced obesity; the fourth group of animals was treated with a solution of sodium citrate intragastric volume of 2.9 ml/kg (solvent of nanocrystalline cerium). We determined the total proteolytic activity, the total antitrypsin activity, the contentfree fucose and glycosaminoglycanes (GAG), content of TBA-active of products, the content of oxidation-modified proteins (OMB), and catalase activity in the homogenate of soft periodontal tissues of rats. Results Intragastric injection of nanoceria prevents activation of proteolytic processes, reducing the catabolism of glycoproteins and proteoglycans of periodontal tissue in MSG-induced obese rats. Injection of nanoceria prevents activation of proteolytic processes, significantly decreases the total proteolytic activity, and inhibits the activation of free radical oxidation in periodontal tissues of rats compared with MSG-induced obesity model without corrections. Further, it significantly increases the total antitrypsin activity in periodontal tissues by 1.7 times, TBA-reagents by 1.7 times, and content of OMB by 1.4 times compared with glutamate-induced obese animals.

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Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016

Abstract: Position paper of the European Association for Predictive, Preventive and Personalised Medicine

Cited by 329 publications

References 74 publications

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Specific protein biomarker patterns for Alzheimer’s disease: improved diagnostics in progress

Efficacy of nanoceria for periodontal tissues alteration in glutamate-induced obese rats—multidisciplinary considerations for personalized dentistry and prevention

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