Mediterranean Anemia

Plasma trapping in the centrifuged red cells of children with severe thalassaemia

“…The mean corpuscular haemoglobin concentration is usually low in thalassaemia (Marmont and Bianchi, 1947;Minnich et al, 1954;Wintrobe, 1961;Sturgeon and Finch, 1957;Lie-Ingo 206 12-Luan Eng, Kho Lien Keng, Liem Djwan Lioe, and Oei Oen Bie, 1959). However, this is not the first time that patients with thalassaemia have been found to have relatively normal mean corpuscular haemoglobin concentrations (Smith, 1943;Dhayagude, 1944;Smith, 1948;Valentine and Neel, 1948;Schwartz and Mason, 1949;Matoth et al, 1955;Siddoo, Siddoo, Chase, Morgan-Dean, and Perry, 1956;Vullo and Tunioli, 1958;Lie-Ingo Luan Eng et al, 1959;Lehmann, 1959;Choremis et al, 1961;Fessas, 1964).…”

Hyperglobulinaemia in Rheumatoid Arthritis

“…Reticulo-endothelial hyperplasia is thought by some workers to play an essential part in the pathogenesis of rheumatoid arthritis (Curletto and Magistretti, 1949;Marmont, 1948;Wallis, 1950;Berglund and others, 1951;Layani and others, 1952). An inflammatory process which originates an ineffective antigen-antibody reaction, perhaps of auto-immune nature, is presumed to be the fundamental mechanism of this hyperplasia.…”

“…It is said to demonstrate the hyperactivity of the reticulo-endothelial system shown by the hyperplasia of its medullary elements (Marmont, 1948;Curletto and Magistretti, 1949). In the course of studying this hyperglobulinaemia by paper electrophoresis, an increase has been observed in the alpha and gamma globulin fractions (Olhagen, 1952;Wallis, 1950;Ropes, Perlmann, Kaufman, and Bauer, 1954;Jacqueline, de Traverse, and Besson, 1954;Hunt and Trew, 1954), or in the beta-gamma globulin fractions (Layani, Bengui, and de Mende, 1952).…”

Revisiting the first reported case of aplastic anaemia

“…1 Diseases initially reported during this period include acute and chronic leukaemias, 2,3 paroxysmal nocturnal haemoglobinuria, 4,5 multiple myeloma, 6 pernicious anaemia 7,8 and myelofibrosis. 9 Credit for the first clear description of aplastic anaemia is usually given to Paul Ehrlich (1854Ehrlich ( -1915, 10 who at the time of the seminal report was a young pathologist working at Charité Hospital in Berlin, in the Second Internal Medicine department led by Professor Carl Jakob Adolf Christian Gerhardt .…”