Medulloblastoma with extracentral nervous system metastases: clinical presentation and risk factors

Kochbati, L.; Bouaouina, Noureddine; Hentati, Dalenda; Nasr, C.; Besbes, M.; Benna, F; Boussen, Hamouda; Maâlej, M.

doi:10.1016/j.canrad.2006.02.004

Cited by 20 publications

(8 citation statements)

References 22 publications

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“…11,12 The prognosis for patients with extra-neuraxial metastases of medulloblastoma remains extremely poor, with a reported mean survival of 6-9 months. 4,6 The treatment options for systemic medulloblastoma are limited. Chemo-naïve patients should be offered palliative systemic chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Since the original report of cerebellar medulloblastoma with systemic metastases, 3 several such single case reports and case series have been published. [4][5][6] Bone (77%) is the most frequent site of systemic metastases, 4 followed by lymph nodes (33%), bone marrow (20%), lung (17%) and liver (15%). Bony lesions usually involve the axial skeleton, pelvic and shoulder girdle, adjacent ends of long bones, ribs and skull.…”

Section: Discussionmentioning

confidence: 99%

“…It has been hypothesized that metastasis can occur hematologically and lymphogenously during operative manipulation, including shunt procedures. 4,6 Peri-neural spread via the trigeminal nerve is a possible route for metastatic spread to the mandible. Cytomorphologic features on intraoperative imprint smears permit rapid and correct cytodiagnosis of brain tumors including medulloblastomas.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral mandibular metastases in medulloblastoma

Srinivas

Gupta

Rajasekharan

et al. 2009

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bilateral mandibular metastases in medulloblastoma

Srinivas

Gupta

Rajasekharan

et al. 2009

Journal of Clinical Neuroscience

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“…The commonest involved sites are bone, bone marrow and cervical lymph nodes. A complete workup at initial diagnosis is recommended to screen for early metastases [109]. Extracranial dissemination is a very poor prognostic sign and requires aggressive systemic therapy for disease control [91].…”

Section: Discussionmentioning

confidence: 99%

A survey of metastatic central nervous system tumors to cervical lymph nodes

Mondin

Ferlito

Devaney

et al. 2010

Eur Arch Otorhinolaryngol

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In the realm of head and neck diseases, one particularly common clinical presentation is that of the patient with a cervical mass. In children, neck masses often prove to be developmental cysts; in adults, the recent onset of a neck mass can signal a metastasis from a head and neck squamous carcinoma. Less often, both adults and children may present with cervical masses caused by either non-Hodgkin's lymphoma or Hodgkin's disease. There are, of course, less frequently encountered differential diagnostic possibilities; one of the most uncommon of all is the possibility of metastasis from an intracranial tumor. Intracranial tumors rarely give rise to cervical node metastases. The present review examines the published experience with 128 tumors that gave rise to cervical node metastases in both adult and in pediatric patients. While it is presumed that the blood-brain barrier blocks the spread of most tumors beyond the intracranial locale, this is speculative. Although many of the cervical node metastases reported here arose after craniotomy (and, presumably, after breaching of the blood-brain barrier), some arose in the absence of any preceding surgical procedure. Cervical node metastases may arise from glial tumors (including glioblastoma multiforme, in both adult and pediatric patients) and non-glial tumors (such as medulloblastoma in pediatric patients). The history of a previous intracranial lesion is often the key to correct diagnosis, since, without prompting, neither the pathologist nor the radiologist is likely to think of a cervical node metastasis from a brain tumor when assessing a cervical mass of unknown etiology.

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“…Previous studies 9,10 report that the systemic metastases can occur from 3 to 5% of the medulloblastoma population, but there is a lack of reports concerning some aspects of the disease, as histological type, tumor topography and survival rate. These blanks in the details of patients with systemic metastasis of medulloblastoma leave incomplete the clinical profile or the natural history of this severe condition.…”

Section: Discussionmentioning

confidence: 99%

Extraneural metastases in medulloblastoma

Muoio

Shinjo²,

Matushita³

et al. 2011

Arq. Neuro-Psiquiatr.

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Medulloblastoma is the most common childhood malignant tumor of central nervous system, but it may also occur in adults. It presents high invasive growth with spreading of tumor cells into the leptomeningeal space along the neuroaxis early in the course of the disease. Extraneural metastases are rare but frequently lethal, occurring only in 1 to 5% of patients, and are related, in the most of cases, to the presence of ventriculoperitoneal shunt. Here we characterize the clinical profile of five cases of medulloblastoma with systemic spreading of tumor cells, also comparing them to cases already described in the literature. Key words: medulloblastoma, metastasis, extraneural.Mestástases extraneurais em moduloblastoma RESUMO O meduloblastoma é o tumor maligno mais frequente do sistema nervoso central na infância, mas também pode ocorrer em adultos. Ele apresenta crescimento altamente invasivo com disseminação de células tumorais ao longo do neuroeixo precocemente no curso da doença. Metástases extraneurais são raras mas frequentemente letais, ocorrendo apenas em 1 a 5% dos pacientes, e estão relacionadas, na maioria dos casos, a presença de derivação ventriculperitoneal. Neste artigo ,apresentamos o perfil de cinco casos de meduloblastoma com disseminção sistêmica das células tumorais, comparando-os com os casos já descritos na literatura. Palavras-chave: medulloblastoma, metastases, extraneural.

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Medulloblastoma with extracentral nervous system metastases: clinical presentation and risk factors

Cited by 20 publications

References 22 publications

Bilateral mandibular metastases in medulloblastoma

Bilateral mandibular metastases in medulloblastoma

A survey of metastatic central nervous system tumors to cervical lymph nodes

Extraneural metastases in medulloblastoma

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