We summarise observations and our current understanding of the interstellar medium (ISM) in galaxies, which mainly consists of three phases: cold atomic or molecular gas and clouds, warm neutral or ionised gas, and hot ionised gas. These three gas phases form thermally stable states, while disturbances are caused by gravitation and stellar feedback in form of photons and shocks in stellar winds and supernovae. Hot plasma is mainly found in stellar bubbles, superbubbles, and Galactic outflows/fountains and is often dynamically unstable and is over-pressurised. In addition, in galactic nuclear regions, accretion onto the supermassive black hole causes enhanced star formation, outflows, additional heating, and acceleration of cosmic rays.