Research points to the importance of adequate health care in women’s prisons. This is especially important as female inmates are faced with a host of unique and distinct needs, in particular, an increased risk of HIV/AIDS infection. This risk presents a significant public health concern as the majority of female offenders receive limited screening, treatment, education, and counseling related to HIV/AIDS infection and transmission while in prison. Additionally, when these women return to their communities, they are generally ill-equipped to prevent the transmission of their disease. Further, their heath concerns become the responsibility of an already overburdened public health system. Effective medical care in prison alleviates inmates’ growing medical needs and protects the public from the transmission of HIV/AIDS. This study identifies the current state of HIV/AIDS among female inmates in correctional institutions nation wide. We argue that mandatory AIDS screening for all inmates and gender-specific educational programming will lower the rate of transmission and the prevalence of high-risk behaviors, thus reducing pre- and post-release health threats. Future research directions and policy implications are discussed.