Mefenamic acid in rheumatoid arthritis.

Myles, A. B.; Bacon, P. A.; Williams, Kristina

doi:10.1136/ard.26.6.494

Cited by 22 publications

(4 citation statements)

References 6 publications

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“…Fenamates give an example of such compounds; until 2012, they were used as non-steroidal anti-inflammatory drugs for pain relief. Due to a number of side effects, their use was ceased in some countries [7][8][9]. Recently, anti-cancer activity of fenamates was revealed [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

et al. 2022

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Mefenamic acid has been used as a non-steroidal anti-inflammatory drug for a long time. However, its practical use is quite limited due to a number of side effects on the intestinal organs. Conformational polymorphism provides mefenamic acid with unique properties regarding possible modifications obtained during the micronization process, which can improve pharmacokinetics and minimize side effects. Micronization can be performed by decompression of supercritical fluids; methods such as rapid expansion of the supercritical solution have proven their efficiency. However, this group of methods is poorly applicable for compounds with low solubility, and the modification of the method using a pharmaceutically suitable co-solvent may be useful. In our case, addition of only 2 mol % dimethyl sulfoxide increased the solubility remarkably. Information on the conformational state may be critically important for carrying out micronization. In this work, structural analysis and estimate of conformational preferences of mefenamic acid in dimethyl sulfoxide − d6 (at 25 °C and 0.1 MPa) and in a mixed solvent supercritical carbon dioxide + dimethyl sulfoxide-d6 (45 °C, 9 MPa) were performed based on nuclear Overhauser effect spectroscopy. Results show changes in the conformation fractions depending on the medium used. The importance of allowing for hidden conformers in estimating the conformational state was demonstrated in the analysis. Obtained results may be useful for improving micronization parameters.

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Section: Introductionmentioning

confidence: 99%

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

et al. 2022

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“…In clinical. trials Cahill, Hill, Jessop, and Kendall (1965), Barnardo, Currey, Mason, Fox, and Weatherall (1966), and Myles, Bacon, and Williams (1967) have suggested that it is of comparable value to aspirin and phenylbutazone, but has a very low incidence of upper intestinal side-effects, which are common with the majority of drugs used in chronic rheumatic diseases. In view of the pogsible relation between mefenamic acid and haemolytic anaemia long-term therapy with this drug should be undertaken with caution and the patients should be watched carefully for evidence of haemolysis.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Haemolytic Anaemia and Mefenamic Acid Therapy

Scott¹,

Myles²,

Bacon³

1968

BMJ

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“…Occasional dyspeptic symptoms and a rather high incidence of diarrhoea accompany its use in man (Bissell, 1965;Myles, Bacon & Williams, 1967). Although in most patients these side-effects are not incapacitating, the drug is obviously a poor alternative to salicylates and indomethacin in patients with peptic ulcer.…”

Section: Other Analgesicsmentioning

confidence: 99%

Gastric ulcer and the anti-arthritic drugs

Emmanuel¹,

Montgomery²

1971

Postgraduate Medical Journal

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Summary Sixteen cases are described of gastric ulcer in patients receiving anti-arthritic drugs. Half of the ulcers were in the antrum or on the greater curve. Ten patients were under treatment with indomethacin and/or prednisone, seven of them receiving both drugs. The ulcers healed readily when the drugs were withdrawn, and in the case of prednisone a continued daily dose of 10 mg or less did not prevent healing. All the patients with haemorrhage were taking aspirin, with or without other drugs. The literature is reviewed, and it is suggested that the increased incidence of peptic ulcer in patients receiving anti-arthritic drugs is confined to gastric ulcer. There is suggestive evidence of an increased susceptibility to antral ulcer in severe rheumatoid disease, which may largely account for the ‘steroid ulcer’. Indomethacin is potentially ulcerogenic, and its combined use with steroids may be inadvisable. Apart from its tendency to produce haemorrhagic erosions, the role of aspirin in the aetiology of chronic ulcer remains doubtful. No serious ill-effects have been reported in the use of ibuprofen or Distalgesic in ulcer subjects.

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Mefenamic acid in rheumatoid arthritis.

Cited by 22 publications

References 6 publications

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

Autoimmune Haemolytic Anaemia and Mefenamic Acid Therapy

Gastric ulcer and the anti-arthritic drugs

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