Megakaryocytic Phagocytosis in a Chromosomally Normal Neonate with Transient Myeloproliferative Disorder

Abstract

We report a case of transient myeloproliferative disorder (TMD) involving the megakaryocytic lineage in a cytogenetically normal newborn infant. Prominent megakaryocytic phagocytosis in the bone marow was observed. This finding might suggest that TMD was due to a self-limiting malignant clone in myelopoiesis.

The effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity of rat bone marrow cells

“…The results of this light microscopy study showed that the cells participating in ME were mostly neutrophil granulocytes and that there was no morphological change in the structure of these cells. In contrast to studies that regarded emperipolesis as phagocytosis,27–29 in the present study no phagosome, the definitive feature of phagocytosis, was observed. In previous light and electron microscopy studies performed on rat and mouse bone marrow, the morphological structures of megakaryocytes and the cells engulfed by them were found to be normal and emperipolesis was defined as being different from phagocytosis 4, 16, 30.…”