Megaprosthesis anti-bacterial coatings: A comprehensive translational review

Lex, Johnathan R.; Koucheki, Robert; Stavropoulos, Nikolaos A.; Michele, Joseph Di; Toor, Jay; Tsoi, Kim; Ferguson, Peter C.; Turcotte, Robert; Papagelopoulos, Panayiotis J.

doi:10.1016/j.actbio.2021.11.045

Cited by 31 publications

(20 citation statements)

References 146 publications

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“…Despite these advantages, concern exists in relation to the risk of drug resistance with routine use and whether therapeutic drug concentrations over the desired timeframe are achievable. It is possible that coatings can prevent infection in the acute phase, but there is a paucity of data regarding their performance in chronic infections [ 267 ]. Prolonged antimicrobial delivery proximal to the implant site usually requires a platform technology to control the presentation of the antimicrobial cargo.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significant burden for patients and healthcare providers. This review delineates the pathogenesis of orthopaedic implant infections and the challenges that arise due to biofilm formation and the implications for treatment. It focuses on research advancements in the development of next-generation orthopaedic medical devices to mitigate against implant-related infections. Key considerations impacting the development of devices, which must often perform multiple biological and mechanical roles, are delineated. We review technologies designed to exert spatial and temporal control over antimicrobial presentation and the use of antimicrobial surfaces with intrinsic antibacterial activity. A range of measures to control bio-interfacial interactions including approaches that modify implant surface chemistry or topography to reduce the capacity of bacteria to colonise the surface, form biofilms and cause infections at the device interface and surrounding tissues are also reviewed.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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“…Resultados in vitro atuais, significado clínico, importância econômica, perspectivas evolutivas e direções futuras de revestimentos antibacterianos vêm sendo discutidos. As estratégias de revestimento antibacteriano ajudarão a reduzir as taxas de infecção após o implante (Lex et al, 2022).…”

Section: Capítulounclassified

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

2022

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

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“…8,13 To this end, physical adsorption on the suture surface with triclosan, Nano-Ag, antibacterial peptides and hydrogels have been reported and several products have come into clinical and preclinical trials. [14][15][16][17] However, this strategy is highly limited for in vivo applications because most antibiotic agents fail to closely adhere to the sutures. The pathway of chemically grafting antibiotic drugs onto surface is severely hampered by the lack of active groups for almost all the commercialized sutures.…”

Section: Introductionmentioning

confidence: 99%