Hybrid suture coating for dual-staged control over antibacterial actions to match well wound healing progression

Abstract

Absorbable sutures have moved to the forefront in surgical fields with a huge market. Antibacterial activity is one indispensable feature of the next generation of absorbable sutures. This study develops...

Core–Shell Filament with Excellent Wound Healing Property Made of Cellulose Nanofibrils and Guar Gum via Interfacial Polyelectrolyte Complexation Spinning

“…Generally, these filaments were prepared using coaxial wet spinning, [ 3,4 ] coaxial electrospinning, [ 5 ] interfacial polyelectrolyte complexation (IPC), water‐evaporation‐controlled self‐assembly, [ 6 ] 3D printing, [ 2 ] and surface‐modification of filaments. [ 7,8 ]…”

Hierarchy of hybrid materials. Part-II: The place of organics-on-inorganics in it, their composition and applications

“…Hybrid nanocomposites based on inorganic NPs with organic molecule modifiers have various functions covering a wide range of applications, particularly in the following sectors and applications: health sector ( Byrappa et al, 2008 ; Kopecek, 2009 ; Chanana et al, 2013 ; Ni et al, 2020 ; Lavrador et al, 2021 ), wound healing applications ( Chen et al, 2022 ), long-term tracking stem cell transplantation therapy in vivo ( Xie et al, 2022 ), electrochemical immunosensing ( Campuzano et al, 2017 ), optics ( Shavel et al, 2004 ; Melnikau et al, 2016 ; Melnikau et al, 2018 ), micro-electronics ( Banerjee et al, 2009 ), transportation, packaging ( Moustafa et al, 2021 ), energy ( Li et al, 2016 ; Mahmood et al, 2016 ; Liu et al, 2019 ), housing ( Saba et al, 2016 ), catalysis ( Shahmoradi et al, 2011 ; Liu et al, 2014 ; Tomai et al, 2021 ) and the environment ( Sanchez et al, 2011 ). Cyclodextrins (CDxs) were reported as solubilizing agents, which could improve C60 water solubility when coated by CDxs ( Ikeda, 2013 ).…”

“…Peculiarly, such modifications have been used even from the time of ancient Greece ( Sanchez et al, 2005 ) to particle-enhanced tires fabricated using carbon black, ZnO, MgS with rubber ( Goodyear, 1856 ), extending to one a very practical material Bakelite produced by Leo Baekeland by admixing clays with resin ( Baekeland, 1909 ). In contemporary research and development areas, functionalities and applications of hybrid materials continue to be extended, including, for example, water purification ( Rigoletto et al, 2022 ) and antibacterial properties ( Chen et al, 2022 ).…”

Culture-Delivery Live Probiotics Dressing for Accelerated Infected Wound Healing

“…22 Recently, extensive delivery scaffolds have been established to support wound healing. 23,24 Hydrogels, in particular, have emerged as the most promising contenders for clinical applications. 25,26 This is due to their remarkable hydrophilicity, biocompatibility, and 3D porous structure to resemble the extracellular matrix, as well as generating a relatively uniform distribution of cells.…”

“…Probiotic therapy has been extensively investigated, while its applications are severely limited by probiotics’ low viability, metabolic activity, and colonization efficiency during processing, storage, and, especially, delivery . Recently, extensive delivery scaffolds have been established to support wound healing. , Hydrogels, in particular, have emerged as the most promising contenders for clinical applications. , This is due to their remarkable hydrophilicity, biocompatibility, and 3D porous structure to resemble the extracellular matrix, as well as generating a relatively uniform distribution of cells . Numerous infected wounds hydrogel dressings for packaging and delivering various antimicrobial substances are becoming highly sought after. − However, large amounts of investigated dressings require 10–30 s to gel, which may pose a threat to the effectiveness of carried live cells or probiotics and significantly retard the convenience of operation. , Moreover, many cultivation and delivery systems lack adequate mechanical performance and protective structural design, severely limiting the long-term viability and leakage prevention of probiotics. , The exposed probiotics on wounds may cause attacks by the immune system, which is detrimental to viability of applied probiotics and even desired therapeutic effectiveness .…”