Megastigmane Glycosides from Docynia indica and Their Anti‐inflammatory Activities

Abstract

Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)‐vomifoliol 9‐O‐β‐d‐xylopyranosyl‐(1′′→6′)‐O‐β‐d‐glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3‐α‐l‐arabinofuranoside (7), naringenin 7‐O‐β‐d‐glucopyranoside (8), phloridzin (9), phloretin 2′‐O‐β‐d‐xylopyranosyl‐(1→6)‐β‐d‐glucopyranoside (10), pinosylvin 3‐O‐β‐d‐glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS‐stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS‐stimulated NO production in BV2 cells with the IC50 values ranging from 21.0 to 29.3 μm.

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

“…Avicularin, also known as quercetin 3-O-α-L-arabinofuranoside, is a flavonoid and quercetin derivative (Guo et al, 2018). Compared with quercetin, avicularin has a stronger anti-inflammatory ability (Dung et al, 2016). The excessive secretion of cytokines in an inflammatory state will lead to depression.…”

Triterpenes From Docynia Indica Fruits and Their Cytotoxic Activity

“…The fruits of D. indica have been used in traditional remedies for the treatment of infectious diseases, digestive disorders, dyhypeslipidemia, and hypertension [1,2]. It was also found to possess biological activities, including anti-inflammatory [3], antioxidant and antimicrobial [4], The study results showed that the fruits of D. indica contain flavonoids, triterpenoids and megastigmane glycosides [3,5]. Catechin and ferulic acid were the major phenolics present in D. indica fruits [4].…”