MEIOTIC DRIVE IN NATURAL POPULATIONS OF<i>DROSOPHILA MELANOGASTER</i>. VIII. A HERITABLE AGING EFFECT ON THE PHENOMENON OF SEGREGATION-DISTORTION

Sandler, L.; Hiraizumi, Yuichiro

doi:10.1139/g61-009

Cited by 77 publications

(76 citation statements)

References 8 publications

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“…3 This chromosome causes very weak distortion, with k values around 0.58 (see Tables 2 and 5). Addition of the Sd gene via the P[(w + Sd) 2 ] transgene 7 to the SD-5 r7 chromosome results in a k value of 1.000 (Table 2, line 4). Addition of a mutation that affects nuclear transport should cause similar increases in distortion if a defect in nuclear transport is responsible for the distortion phenotype.…”

Section: Resultsmentioning

confidence: 99%

“…SD was first observed because males carrying one SD chromosome and one normal (SD + ) chromosome failed to transmit the normal chromosome to their offspring, causing transmission ratios of near 100% of the SD chromosome. 2 The SD system has been well-studied at both the genetic 1,3,4 and molecular levels. [5][6][7] SD consists of a collection of genes, all of which reside on the 2 nd chromosome.…”

Section: Introductionmentioning

confidence: 99%

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Defects in nuclear transport enhanceSegregation Distortion

McElroy

McLean²,

McLean³

2008

Fly

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Defects in nuclear transport enhanceSegregation Distortion

McElroy

McLean²,

McLean³

2008

Fly

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“…In the Drosophila melanogaster complex, only a small number of genes involved in intragenomic conflict have been identified within natural populations (e.g., Sandler et al 1959;Mercot et al 1995). While this may suggest that intragenomic conflict is a relatively rare event, it needs to be considered that there is a strong ascertainment bias: The rapid spread of driver alleles is either prevented by a quick fixation of suppressor alleles, or, in case of sex chromosome-linked segregation distorters, populations with an advanced intragenomic conflict become extinct (Gershenson 1928;Hamilton 1967;Lyttle 1977).…”

mentioning

confidence: 99%

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

Nolte¹,

Pandey²,

Kofler³

et al. 2012

Genome Res.

117

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Although it is well understood that selection shapes the polymorphism pattern in Drosophila, signatures of classic selective sweeps are scarce. Here, we focus on Drosophila mauritiana, an island endemic, which is closely related to Drosophila melanogaster. Based on a new, annotated genome sequence, we characterized the genome-wide polymorphism by sequencing pooled individuals (Pool-seq). We show that the interplay between selection and recombination results in a genome-wide polymorphism pattern characteristic for D. mauritiana. Two large genomic regions (>500 kb) showed the signature of almost complete selective sweeps. We propose that the absence of population structure and limited geographic distribution could explain why such pronounced sweep patterns are restricted to D. mauritiana. Further evidence for strong adaptive evolution was detected for several nucleoporin genes, some of which were not previously identified as genes involved in genomic conflict. Since this adaptive evolution is continuing after the split of D. mauritiana and Drosophila simulans, we conclude that genomic conflict is not restricted to short episodes, but rather an ongoing process in Drosophila.

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“…The non-Mendelian segregation of markers, known as distorted segregation, is a common biological phenomenon and has been reported since the early twentieth century (Mangelsdorf and Jones, 1926;Sandler et al, 1959;Rick, 1966;McCouch et al, 1988;Paterson et al, 1988;Brummer et al, 1993;Xu et al, 1997;Kaló et al, 2000;Lu et al, 2002;Barchi et al, 2010). It may lead to a biased estimate of the recombination fraction and affect the accuracy of linkage groups (Lorieux et al, 1995a,b).…”

Section: Introductionmentioning

confidence: 99%

Linkage group correction using epistatic distorted markers in F2 and backcross populations

Zhang

2014

Heredity

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Epistasis has been frequently observed in all types of mapping populations. However, relatively little is known about the effect of epistatic distorted markers on linkage group construction. In this study, a new approach was proposed to correct the recombination fraction between epistatic distorted markers in backcross and F 2 populations under the framework of fitness and liability models. The information for three or four markers flanking with an epistatic segregation distortion locus was used to estimate the recombination fraction by the maximum likelihood method, implemented via an expectation-maximisation algorithm. A set of Monte Carlo simulation experiments along with a real data analysis in rice was performed to validate the new method. The results showed that the estimates from the new method are unbiased. In addition, five statistical properties for the new method in a backcross were summarised and confirmed by theoretical, simulated and real data analyses.

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MEIOTIC DRIVE IN NATURAL POPULATIONS OFDROSOPHILA MELANOGASTER. VIII. A HERITABLE AGING EFFECT ON THE PHENOMENON OF SEGREGATION-DISTORTION

Cited by 77 publications

References 8 publications

Defects in nuclear transport enhanceSegregation Distortion

Defects in nuclear transport enhanceSegregation Distortion

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

Linkage group correction using epistatic distorted markers in F2 and backcross populations

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