Mekabu fucoidan: Structural complexity and defensive effects against avian influenza A viruses

Synytsya, Andriy; Bleha, Roman; Synytsya, Alla; Pohl, Radek; Hayashi, Kyoko; Yoshinaga, Koji; Nakano, Takahisa; Hayashi, Toshimitsu

doi:10.1016/j.carbpol.2014.05.032

Cited by 78 publications

(60 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, fucoidans were reported to be able to inhibit avian IAV replication through enhancing immune system in mice19. Thus, we also explored whether KW could improve antiviral immune system by detecting the production of interferon γ (IFN-γ) and interleukin 2 (IL-2) in IAV infected mice.…”

Section: Resultsmentioning

confidence: 99%

“…reported that a fucoidan isolated from Undaria pinnatifida possessed anti-IAV activities in mice with normal and compromised immunity18. Synytsya and co-workers reported that the Mekabu fucoidan could inhibit avian IAV replication through enhancing immune system in mice19. Moreover, fucoidans could be used as vaccine adjuvants to activate spleen cells and enhance antigen-specific antibody production in mice20.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway

Wang

Zhang

et al. 2017

Sci Rep

115

View full text Add to dashboard Cite

Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellmaniella crassifolia effectively blocked IAV infection in vitro with low toxicity. KW possessed broad anti-IAV spectrum and low tendency of induction of viral resistance, superior to the anti-IAV drug amantadine. KW was capable of inactivating virus particles before infection and blocked some stages after adsorption. KW could bind to viral neuraminidase (NA) and inhibit the activity of NA to block the release of IAV. KW also interfered with the activation of EGFR, PKCα, NF-κB, and Akt, and inhibited both IAV endocytosis and EGFR internalization in IAV-infected cells, suggesting that KW may also inhibit cellular EGFR pathway. Moreover, intranasal administration of KW markedly improved survival and decreased viral titers in IAV-infected mice. Therefore, fucoidan KW has the potential to be developed into a novel nasal drop or spray for prevention and treatment of influenza in the future.

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway

Wang

Zhang

et al. 2017

Sci Rep

115

View full text Add to dashboard Cite

show abstract

“…The peaks at 1460, 1370, and 1330 cm −1 corresponded to bending vibrations of O-CH 3 , CH, and aliphatic OH in lignin and cellulose, respectively [35]. The peaks at 1284 and 1082 cm −1 , together with that recorded at 815 cm −1 indicated the presence of sulfated groups [37,38]. Other bands observed in the Raman spectra were less indicative to identify the functional groups present in LS2 and LS5.…”

Section: Chemical and Spectroscopic Features Of Hsmentioning

confidence: 95%

Metabolite-Targeted Analysis and Physiological Traits of Zea mays L. in Response to Application of a Leonardite-Humate and Lignosulfonate-Based Products for Their Evaluation as Potential Biostimulants

et al. 2019

View full text Add to dashboard Cite

The main aim of this study is to identify and investigate specific humates (Hs) as potential biostimulants. Five specialty lignosulfonates (LS1-5), one commercial leonardite-humate (PH), and one commercial lignosulfonate (LH), were analyzed for their carbon, nitrogen, and sulfur contents, and the distribution of functional groups using Fourier transform infrared (FTIR) and Raman spectroscopies. Hs were further supplied for two days to Zea mays L. in hydroponics to test their capacity to trigger changes in physiological target-responses. LS1, LS2, LS3, and LS5 determined the most pronounced effects on plant growth and accumulation of proteins and phenolics, perhaps because of their chemical and spectroscopic features. Root growth was more increased (+51–140%) than leaf growth (+5–35%). This effect was ascribed to higher stimulation of N metabolism in roots according to the increased activity of N-assimilation enzymes (GS and GOGAT) and high consumption of sugars for energy-dependent processes. Increased values of RuBisCO, SPAD (Soil Plant Analysis Development values), and leaf sugar accumulation refer to enhanced photosynthesis attributed to Hs. We conclude that Hs tested in this study functioned as biostimulants, but the specialty lignosulfonates were more efficient in this role, possibly because of the type of starting material and process used for their production, which may have influenced their chemical properties.

show abstract

“…They have received significant biotechnological research interest because of their antitumor [14], immunomodulatory [15], antioxidant [16], antivirus [17], anticoagulant [18] and anti-inflammatory [19] effects as well as for being an abundant non-animal origin and non-toxic edible resource [16]. Fucoidans possibly interact with a variety of growth factors such as basic fibroblast growth factor (bFGF) [20] and transforming growth factor-β [21], through mechanisms similar to that of heparin binding, to mediate these beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

et al. 2017

View full text Add to dashboard Cite

Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from Undaria pinnatifida on dermal wounds. Five round dermal wounds were created on the dorsal back of rats, and they were then treated topically with distilled water (DW), Madecasol Care™ (MC) or LMF at 200, 100 and 50 mg/mL, twice a day for a week. There were dose-dependent increases in wound contraction in the groups receiving LMF but not in the MC group, compared with the DW. Histopathological examination revealed that LMF treatment accelerated wound healing, which was supported by increases in granular tissue formation on day four post-treatment but a decrease on day seven, accompanied by an evident reduction in inflammatory cells. In the LMF-treated wounds, collagen distribution and angiogenesis were increased in the granular tissue on days four and seven post-treatment. Immunoreactive cells for transforming growth factor-β1, vascular endothelial growth factor receptor-2 or matrix metalloproteinases 9 were also increased, probably due to tissue remodeling. Furthermore, LMF treatment reduced lipid peroxidation and increased antioxidant activities. These suggested that LMF promotes dermal wound healing via complex and coordinated antioxidant, anti-inflammatory and growth factor-dependent activities.

show abstract

Mekabu fucoidan: Structural complexity and defensive effects against avian influenza A viruses

Cited by 78 publications

References 45 publications

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway

Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway

Metabolite-Targeted Analysis and Physiological Traits of Zea mays L. in Response to Application of a Leonardite-Humate and Lignosulfonate-Based Products for Their Evaluation as Potential Biostimulants

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

Contact Info

Product

Resources

About