Melamine-mediated supramolecular assembly of nucleobase-modified poly(<scp>l</scp>-lysine)

Zhu, Ling; Xiao, Yan; Zhang, Jiaxiao; Zheng, Siqi; Lang, Meidong

doi:10.1039/c9py01413f

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…However, nucleobase-containing polypeptides have been also reported to form supramolecular assemblies that are potentially useful as novel biocompatible and biodegradable materials [122][123][124]. Recently, a nucleobasemodified polylysine was designed and synthesized by the polymerization of lysine and successive modification with thymines [125]. The self-assembly of the nucleobase-containing polypeptide chains was driven by melamine molecules containing three thymine-like faces.…”

Section: Self-assembling Nucleopeptides and Pnas In Biomedicinementioning

confidence: 99%

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides

et al. 2021

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Peptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involved in the onset and progression of pathologies of high social impact. Nucleobase-bearing peptides (nucleopeptides) and pseudopeptides (PNAs) offer further interesting possibilities related to their nucleobase-decorated nature for diagnostic and therapeutic applications, thanks to their reported ability to target complementary DNA and RNA strands. In addition, these chimeric compounds are endowed with intriguing self-assembling properties, which are at the heart of their investigation as self-replicating materials in prebiotic chemistry, as well as their application as constituents of innovative drug delivery systems and, more generally, as novel nanomaterials to be employed in biomedicine. Herein we describe the properties of nucleopeptides, PNAs and related supramolecular systems, and summarize some of the most relevant applications of these systems.

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Section: Self-assembling Nucleopeptides and Pnas In Biomedicinementioning

confidence: 99%

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides

et al. 2021

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“…For example, cyanuric acid and barbituric acid derivatives promote the formation of rosette-like selfassemblies of molecules with melamine groups, 75 and of melamine-chaperoned molecular assemblies of thyminemodified polypeptides. 76 Li et al reported another approach to fabricate the porous materials composed of cucurbit [8]uril, which involves the use of a combination of cucurbit [8]uril and its guest molecules. 77 The encapsulation improved the solubility of the inclusion complexes in water.…”

Section: Artificial Chaperone Systems Formentioning

confidence: 99%

“…At the same time, Liu et al demonstrated that the addition of l - or d -amino acids into a nongelator induced supramolecular gel formation. , Additionally, artificial chaperone systems for the formation of various molecular assemblies have been reported. For example, cyanuric acid and barbituric acid derivatives promote the formation of rosette-like self-assemblies of molecules with melamine groups, and of melamine-chaperoned molecular assemblies of thymine-modified polypeptides . Li et al reported another approach to fabricate the porous materials composed of cucurbit[8]uril, which involves the use of a combination of cucurbit[8]uril and its guest molecules .…”

Section: Artificial Chaperone Systems For Synthetic Moleculesmentioning

confidence: 99%

Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules

Nishimura

Akiyoshi

2020

Bioconjugate Chem.

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Molecular chaperones play critical roles in biological functions. They are closely involved in the maintenance of cell homeostasis, proper folding of proteins and nucleic acids, and inhibition of irreversible aggregation in denatured proteins. In addition to protein production, molecular chaperone function is widely recognized as important for peptide and protein drug delivery systems. Therefore, much effort has been made in recent decades to develop chaperone-mimetic molecules that have similar structures and biological functions to natural chaperones. These artificial molecular chaperone systems have been demonstrated to facilitate proper protein and nucleic acid folding, in addition to the formation of higher-order structures of synthetic molecules. Furthermore, the functions of these artificial systems show promising clinical applications in drug delivery and biomolecule detection. This topical review focuses on recent advances in the design, construction, characterization, and potential applications of different artificial molecular systems with distinct functional roles, such as the folding of water-soluble and membrane proteins, nucleic acids, and the self-assembly of synthetic molecules. Strategies used in the construction of some artificial molecule chaperone systems for proteins (such as pairs of amphiphilic molecules or self-assembled nanogels) and their applications as biomaterials are described. Specific examples from each design strategy are also highlighted to demonstrate the mechanisms, challenges, and limitations of the different artificial molecular systems. By highlighting the many new developments that have expanded the applications of the artificial chaperones beyond protein folding, this review aims to stimulate further studies on their design and applications.

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Effect of hydrogen peroxide treatment on the quality of epsilon-poly-L-lysine products

Chang

Liu

et al. 2021

Biochemical Engineering Journal

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Melamine-mediated supramolecular assembly of nucleobase-modified poly(l-lysine)

Abstract: Melamine (M) was used to drive the supramolecular assembly of thymine (T)-modified poly(l-lysine) into fibers or spherical micelles through simply adjusting the substitution degree of T and the concentration of M.

Cited by 4 publications

References 55 publications

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides

Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules

Effect of hydrogen peroxide treatment on the quality of epsilon-poly-L-lysine products

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