1994
DOI: 10.1111/j.1600-0749.1994.tb00071.x
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Melanins in IGR 1 Melanoma Cells

Abstract: Information on the composition of melanins is obtained by analysis both of 4-amino-3-hydroxyphenylalanine (AHP) after hydriodic acid degradation and of pyrrole-2,3,5-tricarboxylic acid (PTCA) after potassium permanganate oxidation. Analysis of thiazole-4,5-dicarboxylic acid (TDCA) and pyrrole-2,3-dicarboxylic acid (PDCA) after permanganate oxidation, provides additional information on the composition, TDCA on pheomelanin residues, and PDCA on indolic residues without carboxy groups. Using model melanins formed… Show more

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Cited by 9 publications
(11 citation statements)
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“…As a consequence, the estimation of eumelanins and total melanin could be slightly to moderately biased. This could particularly have influenced our results of the regression analysis study if the DHIDHICA ratio is very different in the six melanoma cell lines used in this study, which is quite probable as outlined by Odh et al (1994). In this paper, very different DHI/DHICA ratios were found in analyzed eumelanins, depending on culture conditions.…”
Section: Comparison Of Hplc and Stereological Data By Linear Regressimentioning
confidence: 63%
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“…As a consequence, the estimation of eumelanins and total melanin could be slightly to moderately biased. This could particularly have influenced our results of the regression analysis study if the DHIDHICA ratio is very different in the six melanoma cell lines used in this study, which is quite probable as outlined by Odh et al (1994). In this paper, very different DHI/DHICA ratios were found in analyzed eumelanins, depending on culture conditions.…”
Section: Comparison Of Hplc and Stereological Data By Linear Regressimentioning
confidence: 63%
“…Numerous hypotheses, not exclusive to each other, may be put forward to explain these results and are given below by increasing order of likelihood. First, one can mention that the HPLC determination of eumelanins was done by the estimation of DHICA units (PTCA) when the DHII DHICA ratio is variable in mammals (Odh et al, 1994;Ozeki et al, 1996Ozeki et al, , 1995Wilczek et al, 1996). As a consequence, the estimation of eumelanins and total melanin could be slightly to moderately biased.…”
Section: Comparison Of Hplc and Stereological Data By Linear Regressimentioning
confidence: 99%
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“…In this review, the contents of eumelanin and pheomelanin are summarized. Several laboratories have adopted our methods for eumelanin and pheomelanin assays (15,23,26,(51)(52)(53)(54)(55)(56)(57). Others use one of the melanin assay methods (58-62) combined with spectrophotometric methods (12,63) or an alkaline hydrogen peroxide oxidation method which degrades eumelanin into PTCA (58,62).…”
Section: Commentsmentioning
confidence: 99%
“…Quantitative measures of DHI and DHICA content in human melanin are complicated by the needed extraction; however, chemical analysis studies suggest a higher level of DHICA-derived eumelanin in human melanoma than in normal melanocytes in skin and hair. 29 31 In addition, dopachrome tautomerase (DCT), a specific enzyme which catalyzes eumelanin biosynthesis to yield DHICA-derived eumelanin, is highly expressed in treatment-resistant, cultured melanoma cells. 32…”
Section: Introductionmentioning
confidence: 99%