2012
DOI: 10.1016/j.mce.2011.07.036
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Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP – Protein kinase A pathway

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Cited by 63 publications
(74 citation statements)
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“…By contrast, an analog of ACTH increased Bdnf mRNA levels in rat glial cell cultures (Shadrina et al 2001) and after cerebral ischemia (Dmitrieva et al 2010). Concordantly, we showed that MC4R activation induces expression of BDNF in cultured rat astrocytes (Caruso et al 2012), suggesting that neuroprotection by MC4R can involve neurotropic factor release.…”
Section: Mc4r and Neuroprotectionsupporting
confidence: 64%
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“…By contrast, an analog of ACTH increased Bdnf mRNA levels in rat glial cell cultures (Shadrina et al 2001) and after cerebral ischemia (Dmitrieva et al 2010). Concordantly, we showed that MC4R activation induces expression of BDNF in cultured rat astrocytes (Caruso et al 2012), suggesting that neuroprotection by MC4R can involve neurotropic factor release.…”
Section: Mc4r and Neuroprotectionsupporting
confidence: 64%
“…CREB is activated by a-MSH in hypothalamic neurons, and although a-MSH decreased TNF-a expression, it did not affect NF-kB activation in these cells . In astrocytes, a-MSH increases cAMP intracellular levels and also induces CREB activation (Caruso et al 2012). Congruently, we blocked BDNF expression induced by MC4R activation in astrocytes with adenylate cyclase and PKA inhibitors (Caruso et al 2012), confirming that the cAMP-PKA-CREB pathway is activated in astrocytes by MC4R stimulation.…”
Section: Mechanisms Of Mc4r-mediated Effectssupporting
confidence: 51%
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