2021
DOI: 10.1080/09273948.2020.1849735
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Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis

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Cited by 28 publications
(22 citation statements)
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“…While MC5r-knockout mice recover on their own from EAU, like wild type mice, they lack the presence of the suppressor APC and the antigen-specific Treg cells within their spleens (100,114,115). While a-MSH treatment suppressed EAU in the knockout mice it does not protect the retina from the damage of inflammation, not did it promote recovery of RPE mediated suppression of phagolysosome activation (91). These results suggest that while the use of a-MSH in therapy to suppress inflammation is possible through its other receptors, it appears that the recovery of immune privilege is dependent on a-MSH working through MC5r.…”
Section: Recovery Of Rpe Mediated Immune Regulationmentioning
confidence: 99%
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“…While MC5r-knockout mice recover on their own from EAU, like wild type mice, they lack the presence of the suppressor APC and the antigen-specific Treg cells within their spleens (100,114,115). While a-MSH treatment suppressed EAU in the knockout mice it does not protect the retina from the damage of inflammation, not did it promote recovery of RPE mediated suppression of phagolysosome activation (91). These results suggest that while the use of a-MSH in therapy to suppress inflammation is possible through its other receptors, it appears that the recovery of immune privilege is dependent on a-MSH working through MC5r.…”
Section: Recovery Of Rpe Mediated Immune Regulationmentioning
confidence: 99%
“…Histological evaluation of the eyes from rodents immunized to induce EAU show that the loss of the RPE monolayer is progressive along with the chronic nature of EAU (Figure 2) (89)(90)(91). Very little damage to the RPE is seen in the early stages of EAU (Figures 2A-C); however, As the disease progresses through the chronic phase, there is severe damage of both INL cells and photoreceptor cells, with the RPE shows damage with pigmentladen macrophages near the damaged RPE (Figure 2D).…”
Section: Experimental Autoimmune Uveitismentioning
confidence: 99%
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