Melanocytic matricoma: a rare tumor that can mimic melanoma

Aranguren-López, Iñigo; Ibarbia-Oruezabal, Sara; Segués-Merino, Nerea

doi:10.1016/j.abd.2022.08.001

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Between these two types of cells, heavily pigmented dendritic melanocytes used to be found. 2,3 The origin of tumors with matrical differentiation may be the hyperactivation of the WNT signaling pathway, which plays a regulatory role in the hair cycle. b-catenin activates transcription factors such as LEF-1.…”

Section: Discussionmentioning

confidence: 99%

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Nodular pigmented lesion on the cheek

Lara Moya,

López‐Llunell,

Sáez Artacho

2023

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

“…Basaloid cells show scant to moderate cytoplasm, nuclear pleomorphism, and mitotic activity. Between these two types of cells, heavily pigmented dendritic melanocytes used to be found 2,3 …”

Section: Discussionmentioning

confidence: 99%

Nodular pigmented lesion on the cheek

Lara Moya,

López‐Llunell,

Sáez Artacho

2023

Int J Dermatology

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“…To the best of our knowledge, there has been only 3 of the 32 cases that have been reported worldwide with atypical features (Table 1). 1–24 This case provides evidence of atypical cytological characteristics in both matrical and keratinous cell populations to propose the “atypical/borderline” category.…”

Section: Introductionmentioning

confidence: 88%

“…Melanocytic matricoma is a unique adnexal cutaneous tumor that was first described by Carlson et al in 1999. 1 It exhibits follicular matrix differentiation with an admixed dual population of epithelial matrical and supramatrical cells (basaloid component), intermediate and anucleated “shadow cells” (keratinocytic component), and prominent dendritic melanocytic hyperplasia. 2 It mainly occurs in middle-aged adults and the elderly in prior sun-damaged skin with male predominance.…”

Section: Introductionmentioning

confidence: 99%

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Nogales-Moro

Pinilla-Pagnon

Silvestre-Torner

et al. 2023

The American Journal of Dermatopathology

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Melanocytic matricoma with atypical features is a rare, biphasic adnexal neoplasm displaying hair matrix differentiation, with only 3 reported cases worldwide. Generally, the lesion comprised a solid matrical and supramatrical cell proliferation, admixed with intermediate cell aggregates with sparse anucleated "shadow cells" and a prominent pigmented melanocytic hyperplasia. We report the case of a 78-year-old man with a slow-growing crusted lesion on the frontal left scalp, which in a matter of 1-2 months became a 0.6 cm well-defined, black purplish exophytic nodule. Histopathologically, the lesion presented a well-circumscribed border with a nodular dermal growth pattern, presenting different architectural features varying from benign pilomatricoma-like changes to atypical features such as moderate-to-high nuclear pleomorphism in both basaloid (matrical/supramatrical) and epidermal (keratinous) components. Strong nuclear and cytoplasmic positivity for b-catenin was observed in matrical cells, whereas prominent cytoplasmic membrane positivity for Melan-A in dendritic melanocytes. Owing to the evidence of atypical cytological features, we propose the "atypical/borderline" category of melanocytic matricoma as part of a possible spectrum among matrical neoplasms. Pathologists should be aware of any atypical histopathological features while reporting cases due to their potential malignant transformation.

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