Melanocytic nevi in very young children: The role of phenotype, sun exposure, and sun protection

Whiteman, David C.; Brown, Robyn M; Purdie, David M.; Hughes, M. C.

doi:10.1016/j.jaad.2004.07.053

Cited by 75 publications

(76 citation statements)

References 27 publications

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“…Previous studies have reviewed the prevalence and distribution of AMN on individual body sites [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24], even in larger BMI patients [25]. Some studies [6,7,12,15,16,17,18] have demonstrated a majority of naevi being present on the trunk compared to other body parts.…”

Section: Discussionmentioning

confidence: 99%

Distribution Analyses of Acquired Melanocytic Naevi on the Trunk

Blake

McClenahan²,

Duffy³

et al. 2014

Dermatology

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Acquired melanocytic naevi (AMN) are a well-known risk factor for the development of melanoma. Whereas previous studies have reviewed AMN distributions on individual body sites, the clinical distribution of AMN on the adult trunk has not been thoroughly investigated. We studied 40 participants with 1,282 naevi >5 mm, of which 781 were located on the trunk. Remarkably, 70% of these truncal naevi were located on the back and we produced a continuous mathematical description of decreasing naevus frequency moving dorsolaterally from the back midline. Furthermore we found that for both sexes the mean naevus size was larger on the front as well as on the lower trunk. This distinct pattern, whilst probably being unwritten knowledge (in the dermatology domain), has not been discussed before.

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Section: Discussionmentioning

confidence: 99%

Distribution Analyses of Acquired Melanocytic Naevi on the Trunk

Blake

McClenahan²,

Duffy³

et al. 2014

Dermatology

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“…The notion that pigment cells at different body sites have different potentials for proliferation (and possibly malignant transformation) is suggested by epidemiological studies of the natural history of nevi in young children, showing different rates of acquisition of nevi for the face versus the trunk (32)(33)(34)(35). These observations have been inferred to implicate melanocytes of the trunk, in the presence of nevi, as being more unstable and having a higher tendency for proliferation and progression than melanomas of the head or neck (32,36).…”

Section: Discussionmentioning

confidence: 99%

Site-Specific Determinants of Cutaneous Melanoma: A Case–Case Comparison of Patients with Tumors Arising on the Head or Trunk

Kvaskoff

Pandeya

Green

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cutaneous melanomas have been hypothesized to arise through different pathways according to phenotype, body site, and sun exposure. To further test this hypothesis, we explored associations between phenotype and melanoma at different sites using a case-case comparative approach.Methods: Melanoma patients (n ¼ 762) aged 18 to 79 years and diagnosed from 2007 to 2010 were ascertained from pathology laboratories in Brisbane, Australia. Patients reported phenotypic information and a dermatologist counted melanocytic nevi and solar keratoses. We compared data for patients with trunk melanoma (n ¼ 541, the reference group), head/neck melanoma (n ¼ 122), or lentigo maligna melanoma (LMM) of the head/neck (n ¼ 69). ORs and 95% confidence intervals were calculated using classical or polytomous logistic regression models.Results: Compared with trunk melanoma patients, those with head/neck melanoma were significantly less likely to have high nevus counts (135: OR ¼ 0.27; P trend ¼ 0.0004). Associations between category of nevus count and LMM head/neck were weaker and significantly different (135: OR ¼ 1.09; P trend ¼ 0.69; P homogeneity ¼ 0.02). Patients with head/neck melanoma were more likely than those with truncal melanoma to have high solar keratosis counts (7: OR ¼ 1.78, P trend ¼ 0.04). Again, associations with LMM head/neck were weaker, albeit not significantly different (7: OR ¼ 1.61; P trend ¼ 0.42; P homogeneity ¼ 0.86).Conclusion: Trunk melanomas are more strongly associated with nevus counts than head/neck melanomas, but are less strongly associated with number of solar keratoses, a marker of chronic sun exposure.Impact: These findings underscore the notion that melanomas on the trunk typically arise through a causal pathway associated with nevus propensity, whereas melanomas on the head/neck arise through a pathway associated with cumulative sun exposure. Cancer Epidemiol Biomarkers Prev; 22(12); 2222-31. Ó2013 AACR.

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“…Only three longitudinal studies of nevus development in infants and very young children have been published (11)(12)(13). Most studies involving this age group have only reported nevus prevalence (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Sun Exposure and the Incidence of Melanocytic Nevi in Young Australian Children

Harrison

MacLennan

Buettner

2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The number of melanocytic nevi (MN) is an important risk factor for cutaneous melanoma. The present study further investigated the relationship between sun exposure, the incidence of MN, and the prevalence of large acquired MN (z5 mm). A cohort of 479 preschool children born in Townsville, Australia was examined for MN in 1991 and a year later. Sun exposure was assessed by questionnaire. The erythemally effective dose of solar UV radiation was estimated from questionnaire data combined with local UV biometry. Almost all (97.7%) children had acquired new MN (median, 12), with a median incidence rate of 11.0 per year (interquartile range, 7.0-16.5). Total number of hours of sun exposure during follow-up (P = 0.034) and tendency to burn (P = 0.028) were independent risk factors for MN incidence. Sunburn experience during follow-up failed to reach significance when adjusted for tendency to burn. Lifetime number of sunburns (P < 0.001) and the severity of sunburns experienced during follow-up (P < 0.001) were significantly related to the presence of large acquired MN at follow-up. Reducing the total number of hours of sun exposure is particularly relevant in sun-sensitive children and may restrain the development of MN, whereas avoiding sunburn in young children might prevent large MN, subsequently reducing the risk of melanoma. (Cancer Epidemiol Biomarkers Prev 2008;17(9):2318 -24)

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Melanocytic nevi in very young children: The role of phenotype, sun exposure, and sun protection

Cited by 75 publications

References 27 publications

Distribution Analyses of Acquired Melanocytic Naevi on the Trunk

Distribution Analyses of Acquired Melanocytic Naevi on the Trunk

Site-Specific Determinants of Cutaneous Melanoma: A Case–Case Comparison of Patients with Tumors Arising on the Head or Trunk

Sun Exposure and the Incidence of Melanocytic Nevi in Young Australian Children

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