Melanocytoma of cerebellum

Rai, Sharada; Sharma, Mamta; Naik, Ramadas; Sinha, Ruchi; Philipose, Raji P.; Verghese, R.

doi:10.4103/0377-4929.40394

Cited by 4 publications

(2 citation statements)

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“…La plupart des mélanocytomes se développe dans le compartiment intradural extramédullaire au niveau du rachis cervical et thoracique [ 5 ]. De façon moins fréquente, ils surviennent dans les leptoméninges supra-tentorielles, dans la fosse postérieure ou le cavum de Meckel [ 6 ]. La symptomatologie neurologique dépend de la localisation tumorale.…”

Section: Discussionunclassified

Mélanocytome méningé: évolution agressive d’une tumeur bénigne: à propos de 2 cas

Khoulali¹,

Haouas²,

Mortada³

et al. 2018

Pan Afr Med J

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Les mélanocytomes méningés sont des tumeurs pigmentées rares qui affectent le système nerveux central et se développent dans les leptoméninges cérébrospinales. Nous présentons deux cas de mélanocytomes méningés montrant une très grande diversité évolutive: une très longue évolution locale d'une lésion méningée cérébrale, avec transformation maligne ayant entrainé le décès après 32 ans pour le premier malade, et la localisation intra-médullaire ectopique à diffusion méningée massive très rapide, pour la deuxième malade. Ces deux cas montrent le profil évolutif incertain des mélanocytomes méningés et ces lésions peuvent devenir agressives dont le pronostic est sombre malgré des thérapeutiques intensives.

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Section: Discussionunclassified

Mélanocytome méningé: évolution agressive d’une tumeur bénigne: à propos de 2 cas

Khoulali¹,

Haouas²,

Mortada³

et al. 2018

Pan Afr Med J

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“…RT = Radiotherapy; Surgery = Surgery without report of extent of resection. References [ 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 ,…”

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confidence: 99%

How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies

Ricchizzi

Gallus

Stummer

et al. 2022

Cancers

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Background: Meningeal melanocytomas (MM) are rare primary melanocytic tumors of the leptomeninges with an incidence of 1:10,000,000. Until now, there has been only sparse information about this tumor entity. Here, we provide a meta-analysis of all cases published in the English language since 1972. Methods: A literature review was performed using PubMed and Web of Science. All published cases were evaluated for location, sex, age, therapeutic approach, and outcome. In total, we included 201 patient cases in our meta–analysis. Results: The majority of MM was diagnosed more frequently in men between the third and fifth decade of life. Surgery is the preferred therapeutic approach, and total resection is associated with the best outcome. Patients with partial resection or tumor recurrence benefit from adjuvant radiotherapy, whereas chemo- or immunotherapies do not improve the disease course. Malignant transformation was described in 18 patients. Of these, 11 patients developed metastasis. Conclusions: We present the first retrospective meta-analysis of all MM cases published in the English language, including an evaluation of different treatment strategies allowing us to suggest a novel treatment guideline highlighting the importance of total resection for recurrence–free survival and characterizing those cases which benefit from adjuvant radiotherapy.

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