Melanoma-associated retinopathy associated with intranasal melanoma

Abstract

Our case demonstrates that MAR can be associated with an intranasal mucosal melanoma. Thus, in cases where the primary lesion cannot be identified in patients with MAR-like symptoms and signs, we recommend that preferential sites of mucosal melanomas be examined.

Presumed melanoma-associated retinopathy (MAR): a presenting sign of primary small intestinal melanoma?

“…2). The full-field ERG showed extinguished rod response with negative waveform on maximal response which was compatible with loss of the on-response as previously described in MAR [11]. The cone ERG's were also diminished with attenuation of both on-and off-responses (Fig.…”

“…The retinopathy usually develops after the diagnosis of cancer; however, there are few reports of retinopathy presented before tumor diagnosis, and only three of them were associated with melanoma [4,5,11].…”

“…Only three cases had been described where the retinal symptoms preceded the diagnosis of melanoma [4,5,11]. There are also reports of cases in which the ocular symptoms preceded diagnosis of metastases or recurrence of skin melanoma even after prolonged disease-free period [19,20].…”

Inverse pattern of photoreceptor abnormalities in retinitis pigmentosa and cone–rod dystrophy

“…Full-field ERGs were recorded after pupillary dilation with 1 % tropicamide and 2.5 % phenylephrine hydrochloride using a light-emitting diode–built-in contact lens electrode (Mayo Nagoya Japan) [6–8]. The reference and ground electrodes were attached to the patients’ forehead and earlobe, respectively.…”

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

“…132 OCT may demonstrate normal retinal architecture and thickness in the early stages of disease, but progressive thinning of the inner retina around the paramacular region can be a later finding. 162 The ERG pattern in MAR is classically electronegative, resembling that seen in congenital stationary night blindness (CSNB), central retinal artery occlusion, and juvenile x-linked retinoschisis. A preserved dark-adapted a-wave, indicating normal photoreceptor function, is followed by a markedly attenuated b-wave, reflecting either bipolar cell dysfunction or disruption of synaptic transmission between photoreceptors and the bipolar cells.…”