Melanoma Cells Inhibit NK Cell Functions—Letter

Sconocchia, Giuseppe; Arriga, Roberto; Tornillo, Luigi; Terracciano, Luigi; Ferrone, Soldano; Spagnoli, Giulio C.

doi:10.1158/0008-5472.can-12-1181

Cited by 62 publications

(56 citation statements)

References 7 publications

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“…However, this is not unique of CRC cells, since CD56 antigen has been found to be heterogeneously expressed by RCC, melanoma, myeloid leukemia cells and bone marrow progenitor cells. 17,18,29 Furthermore, in acute myelod leukemia, CD56 expression has been associated with unfavourable cytogenetic abnormalities, reduced probability to achieve complete remission, and poor survival. 30 We could not test this possibility in CRC since the number of CD56…”

Section: Discussionmentioning

confidence: 99%

“…As already shown in other solid malignancies, most of the CRC cells (>90%) over-expressed MICA/B (data not shown) suggesting that CRC cells are good targets for locally infiltrating NK cells. 4,17,18 Cooperation between NK cells and CD8…”

Section: Expression Of Cd56 In Crc Tumorsmentioning

confidence: 99%

“…In most of these solid malignancies, NK cell infiltration was barely detectable. 4,17,18 Although NK cells have a limited ability to infiltrate the CRC microenvironment, there is a subpopulation of CRC patients with lesions infiltrated with a sufficient number of NK cells suitable for statistical analysis. In prior studies, NK cell infiltration was detected in about 30% of colorectal tumor specimens.…”

Section: Introductionmentioning

confidence: 99%

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NK cells and T cells cooperate during the clinical course of colorectal cancer

et al. 2014

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Recent evidence suggests that natural killer (NK) cells are typically defective in infiltrating solid tumors, with the exception of gastrointestinal stromal tumors (GIST). Interestingly, however, infrequently infiltrating NK cells do not appear to have a direct effect on tumor progression. Here, prompted by the recent evidence that NK cell and T cell crosstalk may trigger, or enhance, tumor antigen-specific immune responses, we have tested the clinical significance of this reciprocal signaling. To this end, a tissue microarray constructed with 1410 colorectal carcinoma (CRC) patient specimens was stained with NK and T cell antigen-specific monoclonal antibodies, utilizing the immunoperoxidase staining technique. Cut-off scores for positive (>4 NK cells) and negative (4 NK cells) NK cell CRC patient samples were determined using receiver operating characteristic curve analysis. Using this approach, NK cells were detected in 423 (30%) of the 1410 CRC specimens evaluated. The number of NK cells was >4 in only 132 (9%) of CRC samples. Correlation of the immunohistochemical staining results together with analysis of the clinical course of the disease revealed that the infiltration of colorectal tumors with both NK cells and CD8C T cells is associated with prolonged patient survival. In contrast, infiltration of tumors with NK cells in combination with CD3C and CD4 C T lymphocytes had no detectable effect on the clinical course of the disease. These results suggest that NK cell and CD8 C T cell crosstalk in the tumor microenvironment may benefit patient outcome and further, that the enumeration of infiltrating NK and CD8 C T cells in CRC tumors may provide useful prognostic information.

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Section: Discussionmentioning

confidence: 99%

Section: Expression Of Cd56 In Crc Tumorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NK cells and T cells cooperate during the clinical course of colorectal cancer

et al. 2014

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“…The role of the innate immune system is unclear. NK-cell infiltration is modest and apparently devoid of prognostic significance (19). Although tumor infiltration by myeloid cells is associated with poor prognosis in a variety of cancers (20), macrophage infiltration has been suggested to correlate with favorable prognosis in colorectal cancer (21).…”

Section: Introductionmentioning

confidence: 99%

The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Governa

Trella

Mele

et al. 2017

Clinical Cancer Research

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“…In contrast, the functional relevance of colorectal cancer infiltration by cells of the innate immune system is still unclear. NK-cell infiltration is relatively rarely detectable and it is devoid of prognostic significance (13). Instead, at difference with a variety of cancers of diverse histologic origin (14), colorectal cancer infiltration by macrophages has been shown to be associated with favorable prognosis (15).…”

Section: Introductionmentioning

confidence: 99%

GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Nebiker

Han

Eppenberger‐Castori

et al. 2014

Clinical Cancer Research

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H-thymidine incorporation. Expression of cytokine genes in colorectal cancer and autologous healthy mucosa was tested by quantitative, real-time PCR. A tumor microarray (TMA) including >1,200 colorectal cancer specimens was stained with GM-CSF-and M-CSF-specific antibodies. Clinicopathological features and overall survival were analyzed.Results: GM-CSF induced CD16 expression in 66% AE 8% of monocytes, as compared with 28% AE 1% in cells stimulated by M-CSF (P ¼ 0.011). GM-CSF but not M-CSF-stimulated macrophages significantly (P < 0.02) inhibited colorectal cancer cell proliferation. GM-CSF gene was expressed to significantly (n ¼ 45, P < 0.0001) higher extents in colorectal cancer than in healthy mucosa, whereas M-CSF gene expression was similar in healthy mucosa and colorectal cancer. Accordingly, IL1b and IL23 genes, typically expressed by M1 macrophages, were expressed to significantly (P < 0.001) higher extents in colorectal cancer than in healthy mucosa. TMA staining revealed that GM-CSF production by tumor cells is associated with lower T stage (P ¼ 0.02), "pushing" growth pattern (P ¼ 0.004) and significantly (P ¼ 0.0002) longer survival in mismatch-repair proficient colorectal cancer. Favorable prognostic effect of GM-CSF production by colorectal cancer cells was confirmed by multivariate analysis and was independent from CD16 þ and CD8 þ cell colorectal cancer infiltration. M-CSF expression had no significant prognostic relevance. Conclusions: GM-CSF production by tumor cells is an independent favorable prognostic factor in colorectal cancer. Clin Cancer Res; 20(12); 3094-106. Ó2014 AACR.

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Melanoma Cells Inhibit NK Cell Functions—Letter

Cited by 62 publications

References 7 publications

NK cells and T cells cooperate during the clinical course of colorectal cancer

NK cells and T cells cooperate during the clinical course of colorectal cancer

The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

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