Melanoma in childhood and adolescence: Clinical and pathological features of 48 cases

Tate, Peter S.; Ronan, Salve G.; Feucht, Kenneth A.; Eng, Ana M.; Gupta, Tapas K. Das

doi:10.1016/s0022-3468(05)80279-9

Cited by 61 publications

(24 citation statements)

References 15 publications

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“…40 In three of five problematic Spitz tumors and in many of the typical melanomas, those authors demonstrated supernumerary aberrations of chromosome 1 suggestive of aneuploidy, whereas Spitz nevi were euploid. 40 When these findings are coupled with reports of atypical, controversial, or problematic Spitz tumors disseminating with a lethal outcome, 2,7,14,15,26,[47][48][49] it is completely reasonable and tenable to regard an atypical Spitz tumor found in the lymph node parenchyma as biologically malignant.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Fullen

Sondak

et al. 2003

Cancer

147

122

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A new device—the rotational particle separator (RPS)—is compared to the cyclone for the removal of ultrafine particles, such as cryogenically condensed contaminant droplets from natural gas. The comparison focusses on identifying for each configuration the smallest size of particle which has a 50% chance of being removed from the gas stream. Whereas a cyclone can only separate 1 μm droplets at very low‐throughputs on the order of 1 MMscfd, at the same energy consumption and device volume, the rotational particle separator removes droplets of that size at throughputs of 300 MMscfd. The advantage of the rotational particle separator, therefore, lies in its compact separation potential for full‐scale industrial gas well throughputs. © 2006 American Institute of Chemical Engineers AIChE J, 2007

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Section: Discussionmentioning

confidence: 99%

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Fullen

Sondak

et al. 2003

Cancer

147

122

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“…5,6 Rates of disease-free survival in children are comparable to those in adults with stage I or II disease: approximately 77 percent at five years. 7 The thickness of the melanoma and the level of invasion are the most important predictors of long-term survival. 8,9 Nodal metastases develop in up to two thirds of children with deeply invasive melanomas (Clark's levels IV and V) or with melanomas more than 1.5 mm thick.…”

Section: Ncidence and P Rognosismentioning

confidence: 99%

“…6,9 The most common histologic subtypes of melanoma occurring in children are superficial spreading melanoma and nodular melanoma. 7,11 …”

Section: Ncidence and P Rognosismentioning

confidence: 99%

Melanoma in Children

Ceballos

Ruíz-Maldonado

Mihm³

1995

N Engl J Med

170

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“…Furthermore, in a review of the literature, we found several patients who had Spitzoid melanoma that initially was misdiagnosed as Spitz nevus, leading to fatal outcomes. [3][4][5][6] Due to these diagnostic difficulties of Spitzoid melanoma clinically and histopathologically, misdiagnoses or delays in diagnosis occur. This diagnostic dilemma is much more obvious in children, because melanomas of all types are extremely rare in this age group, whereas Spitz nevi are common.…”

Section: Discussionmentioning

confidence: 99%

Are all melanomas the same?

Lee

Cohen

Twaddell

et al. 2006

Cancer

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BACKGROUNDAlthough the majority of melanomas demonstrate high rates of mutations in B‐RAF or N‐RAS that result in constitutive activation of the mitogen‐activated protein kinase‐signaling pathway, emerging data suggest molecular differences among melanoma subtypes. In this study, the authors evaluated the contribution of B‐RAF and N‐RAS mutations to the pathogenesis of Spitzoid melanomas.METHODSIn total, 33 Spitzoid melanomas were analyzed for clinical and pathologic characteristics as well as for hot‐spot mutations in the B‐RAF and N‐RAS genes. In the majority of patients (28 of 33 melanomas), the tumors were confined to the skin with no evidence of metastasis (average follow‐up, 32.5 mos). There were five metastasizing melanomas (5 of 33 tumors) with regional or systemic spread.RESULTSOf 33 Spitzoid melanomas, only 1 showed the V600E mutation in the B‐RAF gene (1 of 33 tumors; 3%). It was noteworthy that none of the metastatic Spitzoid melanomas (0 of 5 tumors; 0%), of which 2 resulted in fatal outcomes, demonstrated mutations in B‐RAF or N‐RAS.CONCLUSIONSIn contrast to the majority of cutaneous melanomas, activating hot‐spot mutations in B‐RAF or N‐RAS were not involved in the pathogenesis of Spitzoid melanoma. These data suggested that Spitzoid melanoma is a distinct form of melanoma with unknown genes and/or signaling pathways involved in its development. Cancer 2006. © 2006 American Cancer Society.

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Melanoma in childhood and adolescence: Clinical and pathological features of 48 cases

Cited by 61 publications

References 15 publications

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Melanoma in Children

Are all melanomas the same?

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