Mélanome malin primitif du vagin : à propos d’un cas et revue de la littérature

Primary Malignant Melanoma of the Vagina without Metastasis: A Rare Case and Review of Literature

“…9,10 The diagnosis was often made at an advanced stage as the vagina is characterized by a very rich lymphatic network, considering the high risk of hematogenous extension of melanoma. 3 Currently, the mechanism of pathogenesis and etiological factors for PMMV are unknown. Socioeconomic factors such as level of education, income, and poverty seem to have no influence on incidence rates and race was not a risk factor for primary malignant vaginal melanoma.…”

“…13 There is no standard treatment for PMMV established in the literature, but surgical excision either by local wide excision or radical surgery with colpectomy with/without exenteration is the mainstay of treatment for women with PMMV. 3,4,17 Radiotherapy may have role either as an adjuvant following surgery or when surgery is not feasible due to the disease or patient-related factors. 5,11 Surgery, radiotherapy, and immunotherapy with interferon-α are the mainstay of treatment for localized disease, while chemotherapy with dacarbazine is mostly used for unresectable and recurrent disease.…”

“…2 This neoplasm usually occurs between the sixth and the seventh decade. 3 The more common symptoms are bleeding or vaginal discharge, a vaginal mass felt, dyspareunia, pruritus, or pain. 4 No staging system has been demonstrated to be a useful predictor of prognosis in vaginal melanoma, although tumor size (<3 cm vs. ≥3 cm) has been shown to predict survival in some series.…”