Melanonychia induced by topical treatment of periungual warts with 5-fluorouracil

Anda, M.; Dominguez, J.

doi:10.5070/d389r0m9jq

Cited by 6 publications

(1 citation statement)

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“…Palmar-plantar erythrodysesthesia (PPE), also known colloquially as hand-foot syndrome (HFS), is a cutaneous toxic reaction associated with many common cytotoxic agents such as capecitabine, cytarabine, and docetaxel. The mechanism of action of HFS is not fully understood, but it is believed to occur on the palms and soles due to the transportation of drugs from the eccrine sweat glands to the stratum corneum, where the drugs accumulate and ultimately cause a local cutaneous reaction [1]. This reaction is often characterized initially by paresthesia, which is followed by erythema, edema, and blistering of the hands and feet with resultant epidermal necrosis [2,3].…”

Section: Introductionmentioning

confidence: 99%

Capecitabine-Induced Genital Hand-Foot Syndrome Treated With Topical Tacrolimus

Chan,

Wang

2024

Cureus

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We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadjuvant chemotherapy. Given its severe impact on the quality of life, HFS often requires independent local antiinflammatory treatment and subsequent dose delay and/or modification of the patient's chemotherapy. We believe that our findings in this report can aid clinicians in the early recognition and management of capecitabine-associated HFS resulting in balanitis, as prompt treatment may reduce morbidity and avoid prolonged interruption of chemotherapy in these patients.

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Section: Introductionmentioning

confidence: 99%