Melanotic Neurofibroma in a Steer.

Kameyama, Mamoru; Ishikawa, Yoshiharu; Shibahara, Tomoyuki; Kadota, Koichi

doi:10.1292/jvms.62.125

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Similar representation such as epithelioid type [17], melanotic type [18,19] cartilaginous and osteogenic [20] or glandular epithelial differentiation have been found in MPNSTs in dogs or other animals [3,21]. …”

Section: Introductionmentioning

confidence: 80%

RETRACTED ARTICLE: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

et al. 2013

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Canine Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are uncommonly reported in the ulnar, since they are underestimated relative to the more common spindle cell tumours of soft tissue. In dogs, MPNST accounts for 27% of nervous system tumours. In man, MPNST represents 5-10% of all soft tissue sarcomas and is often associated with neurofibromatosis type 1 (NF-1).An 8-year-old, 9 kg, female mixed-breed dog with a subcutaneous mass on the upper right side of the ulnar region was presented to the small animal research and teaching hospital of Tehran University. The dog was anorexic with general weakness. The mass (7 × 4 cm) was removed surgically and processed routinely. Microscopically, the mass was composed of highly cellular areas with a homogeneous population of round or spindle cells, high cellular pleomorphism, high mitotic index and various morphologic patterns. Furthermore, spindle cells arranged in densely or loosely sweeping fascicles, interlacing whorls, or storiform patterns together with wavy cytoplasm, nuclear palisades, and round cells were arranged in sheets or cords with a meshwork of intratumoral nerve fibers. In addition, in this case the presence of neoplastic cells within the blood vessels was observed. Immunohistochemically, tumor was positive for vimentin and S-100 protein. The histopathologic features coupled with the S-100 and vimentin immunoreactivity led to a diagnosis of malignant neurofibroma.To the best of our knowledge, primary ulnar MPNST has not been reported in animals. This is the first documentation of an ulnar malignant peripheral nerve sheath tumour in a dog.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1310907815984587

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Section: Introductionmentioning

confidence: 80%

RETRACTED ARTICLE: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

et al. 2013

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“…17,25,41 In human MPNSTs, variable histologic patterns and heterogenous differentiation have been reported, [10][11][12]39,42 including epithelioid MPNST 27,29 and MPNST with divergent differentiation such as rhabdomyoblastic (malignant Triton tumor), 5,8,9,24 cartilaginous, osseous, angiomatous, 31 and glandular forms, 6,37,48 or their complex. 47 Similar representation such as epithelioid type, 36 melanotic type, 20,32 cartilaginous and osteogenic, 2 or glandular epithelial differentiation have been found in MPNSTs in dogs or other animals. 25,33,41 Furthermore, atypical cell morphology such as tumor cells with eosinophilic cytoplasmic globules may also occur.…”

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confidence: 77%

Immunohistochemical Evaluation of Canine Peripheral Nerve Sheath Tumors and Other Soft Tissue Sarcomas

2004

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Abstract. Seventeen cases of canine peripheral nerve sheath tumors (PNSTs), 11 malignant PNSTs (MPNSTs), and six benign PNSTs (BPNSTs) were examined. The prognosis in five of six dogs with BPNSTs was excellent, whereas all dogs with MPNSTs died within 2 years after the last surgical resection. One BPNST formed a recurrent mass with features of a MPNST. Histopathologically, the predominant tumor cell of MPNSTs was either spindle or round in shape with epithelioid characteristics. Other atypical cells had abundant granular cytoplasm or were multinucleated giant cells with periodic acid-Schiff-positive cytoplasmic globules. Furthermore, two MPNSTs contained cartilaginous and osseous metaplasia. On the contrary, most BPNSTs exhibited typical features of schwannoma or neurofibroma, whereas two BPNSTs had atypical morphology. One BPNST consisted of epithelioid cell proliferation with some tumor cells revealing nuclear atypia. Immunohistochemically, the expression of vimentin (100%), S-100 (73%), nerve growth factor receptor (NGFR, 64%), and myoglobin (64%) was commonly found in MPNSTs. The two BPNSTs with atypical histologic appearances were positive for vimentin, S-100, NGFR, and neuron-specific enolase, and one of these had moderate immunoreactivity for cytokeratin. Most BPNSTs were positive for glial fibrillary acidic protein, as well as S-100 and NGFR. Although most rhabdomyosarcomas (RMSs) and canine hemangiopericytomas (CHPs) also showed focal immunoreactivity for S-100, most RMSs were intensely positive for myoglobin and negative for NGFR. Most CHPs (80%) exhibited focal ␣-smooth muscle actin (␣-SMA) expression, whereas all PNSTs were negative. These results indicate that immunohistochemistry for NGFR and ␣-SMA might be useful for differentiating canine PNSTs from RMSs or CHPs, respectively.

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“…Cutaneous benign PNSTs are rarely reported in dogs, cats, horses, and cattle. 5,12,30 Cutaneous schwannomas can be observed as spontaneous tumors in mice; 23 a plexiform cutaneous schwannoma has been reported in a pig. 38 In horses, the eyelids are considered a predilection site for cutaneous PNSTs.…”

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confidence: 99%

Cutaneous Schwannomas in 22 Horses

et al. 2010

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Schwannomas are uncommonly recognized in horses. This study describes cutaneous schwannomas in 22 horses aged 8 to 25 years: 12 male, 7 female, and 3 of unknown sex. The horses had solitary cutaneous masses: 9 on the head, 3 on the neck, and the others on the shoulder, hip, thorax, abdomen, rump, extremities, or tail. The location of 1 tumor was unknown. The dermal tumors were well demarcated and expansile. Twelve had a multinodular pattern, whereas 10 formed a single nodule. Antoni A areas were observed in all tumors, and 10 tumors contained Antoni B areas. In Antoni A areas, the densely packed spindle-shaped neoplastic cells were arranged in short fascicles with nuclear palisading. In the hypocellular Antoni B areas, neoplastic cells were separated by abundant myxomatous stroma. Tumors commonly had hyalinization of stroma and vessel walls and ancient change. Cellular vacuolation was observed in 18 tumors. In all 22 cases, neoplastic cells were immunopositive for S100 protein. Expression of laminin and glial fibrillary acidic protein was observed in all 6 tumors evaluated by immunohistochemistry for these markers. One tumor was examined ultrastructurally: Neoplastic cells had branched cytoplasmic processes and were surrounded by an external lamina. Follow-up information was available 8 months to 10 years postexcision for 9 horses, for which surgical excision of the tumor was curative. The equine cutaneous schwannomas in this study had microscopic features like those of human schwannoma and had benign clinical behavior. Correct classification of equine cutaneous schwannoma will facilitate accurate prognosis and appropriate treatment.

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Melanotic Neurofibroma in a Steer.

Cited by 14 publications

References 16 publications

RETRACTED ARTICLE: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

RETRACTED ARTICLE: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

Immunohistochemical Evaluation of Canine Peripheral Nerve Sheath Tumors and Other Soft Tissue Sarcomas

Cutaneous Schwannomas in 22 Horses

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