Melanotropic-Lipolytic Peptides in Various Regions of Bovine, Simian and Human Brains and in Simian and Human Cerebrospinal Fluids

Rudman, Daniel; Rio, Alejandro E. Del; Hollins, Bettye; Houser, Diane H.; Keeling, Michale E.; Sutin, Jerome; Scott, John W.; Sears, Robert A.; Rosenberg, Murray Z.

doi:10.1210/endo-92-2-372

Cited by 42 publications

(3 citation statements)

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“…Hypothalamus itself produces fat mobilizing peptides (Redding Sc Schally 1970;Rudman et al 1973), and the neurophysins originating there have been credited a fat mobilizing activity (Foss et al 1973;Rudman et al 1970). Additionally the biogenic amines produced in the central nervous system have lipid mobilizing activity (Shah et al 1972).…”

Section: Discussionmentioning

confidence: 99%

Lipoatrophy Produced in Mice and Rabbits by a Fraction Prepared From the Urine From Patients With Congenital Generalized Lipodystrophy

Foss¹,

Trygstad²

1975

Acta Endocrinologica

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Urine from 5 patients with congenital generalized lipodystrophy has been fractionated by protein precipitation and Sephadex gel filtration. A fraction with a molecular weight in the range of 1000 was observed to be metabolically active in mice, rats, and rabbits. Hypophysectomized rats got hypoglycaemia following an injection, and the lipolytic-hyperglycaemic effect of ACTH was reduced after injection into intact mice. This effect was probably due to insulin release, because no insulin-like activity was observed on isolated fat cells in vitro. Persistant changes were observed in the animals after 3 weeks of daily injections of the urinary fraction. Adult mice and rabbits developed lipoatrophy with decrease of body weight in spite of a doubling of the food consumption. The metabolic rate and the body temperature were raised. Infantile animals developed a lipodystrophic state with increased growth velocity, and 50 per cent increase of the body weight, although no fat depots were observed. The treated animals got hyperglycaemia, hypertriglyceridaemia, hyperinsulinaemia, and insulin resistance. The rabbits developed manifest diabetes. The corresponding fraction prepared from the urine from the lipoatrophic rabbits produced lipoatrophy after injection into the mice. It is suggested that the lipodystrophic urinary fraction is of hypothalamic origin, and that it acts through the pituitary gland. The fraction is still heterogenous, and was observed to contain thyrotrophin releasing activity.

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Section: Discussionmentioning

confidence: 99%

Lipoatrophy Produced in Mice and Rabbits by a Fraction Prepared From the Urine From Patients With Congenital Generalized Lipodystrophy

Foss¹,

Trygstad²

1975

Acta Endocrinologica

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“…Furthermore, neuro peptides related to ACTH may be produced by tire brain itself. The presence of biologically active and immunoreactive ACTH and MSH-like material in the brain has been repeatedly re ported (Guillemin et al, 1962;Schally et al, 1962;Rudman et al, 1973;Swaab, 1976;Krieger et al, 1977a, b;Loh and Gainer, 1977;Larsson, 1977;Oliver and Porter, 1978).…”

Section: Nature Of Behavioral Effects Of a C Th And Related Peptides mentioning

confidence: 94%

Effects of ACTH-Like Neuropeptides on Animal Behavior and Man

Bohus¹

1979

Pharmacology

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“…19731 . Bioassayable melanotropic peptides and immunoreactive a-MSH have been detected in different brain regions [Loh and Gainer, 1977a, Oliver and Porter, 1978, Shally et a1 1962, Rudman et al, 1973 , and the levels of these peptides appear to persist after hypophysectomy [Krieger et al, 1977;Oliver and Porter, 1978;Ralph and Peyton, 1966;Rudman et al, 19741. This suggests that there is an extrahypophysial source of these peptides in the brain.…”

Section: Introductionmentioning

confidence: 99%

Melanotropic peptides: Presence in brain of normal and hypophysectomized rats, and subcellularly localized in synaptosomes

Loh

Zucker

Verspaget

et al. 1979

J of Neuroscience Research

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A major and several minor trichloroacetic acid (TCA) soluble, bioassayable melanotropic peptides, as well as bioreactive and immunoreactive alpha-MSH have been found in the hypothalamus, olfactory bulb and cerebral cortex of normal and hypophysectomized rats. By employing subcellular fractionation procedures it was demonstrated that alpha-MSH and the major TCA soluble melanotropic peptide (MMPB) were localized in synaptosomes and were released by hypoosmotic shock. The analysis of MMPB by electrophoretic and chromatographic procedures reveales that it is not ACTH4-10, ACTH1-10, ACTH1-24, NAcACTH1-10 or alpha-MSH. MMPB was found to cross-react with an antiserum specific for the Lys-Pro-Val NH2 sequence in alpha-MSH, indicating that this C-terminal sequence of alpha-MSH may be present in its structure. MMPB was also shown to differ electrophoretically from the two major TCA soluble melanotropic peptides found in the neurointermediate lobe of the pituitary. In view of their synaptosomal localizations MMPB and alpha-MSH may play a role in synaptic function in the nervous system.

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Melanotropic-Lipolytic Peptides in Various Regions of Bovine, Simian and Human Brains and in Simian and Human Cerebrospinal Fluids

Cited by 42 publications

References 0 publications

Lipoatrophy Produced in Mice and Rabbits by a Fraction Prepared From the Urine From Patients With Congenital Generalized Lipodystrophy

Lipoatrophy Produced in Mice and Rabbits by a Fraction Prepared From the Urine From Patients With Congenital Generalized Lipodystrophy

Effects of ACTH-Like Neuropeptides on Animal Behavior and Man

Melanotropic peptides: Presence in brain of normal and hypophysectomized rats, and subcellularly localized in synaptosomes

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