Melatonin: A Multitasking Molecule

Reíter, Russel J.; Tan, Dun‐Xian; Fuentes-Broto, Lorena

doi:10.1016/s0079-6123(08)81008-4

Cited by 557 publications

(464 citation statements)

References 151 publications

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“…Melatonin is a hormone secreted by the pineal gland, and regulates a variety of central and peripheral actions related to circadian rhythms and reproduction. Melatonin is a powerful free radical scavenger and a broad-spectrum antioxidant [31,32]. We previously demonstrated that melatonin is present in human ovarian follicles and that its concentration increases during follicular growth [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Tamura

Takasaki

Nakamura

et al. 2014

Journal of Ovarian Research

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Background: Additional treatment with a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) before IVF-ET (ultralong GnRHa therapy) has been reported to improve the outcome of IVF-ET in endometriosis patients. However, the mechanism of ultralong GnRHa therapy is unclear. It is suggested that inflammatory cytokines and oxidative stress contribute to infertility in endometriosis patients. Therefore, in order to search a possible mechanism of ultralong GnRHa therapy, we investigated the effect of ultralong GnRHa therapy on intrafollicular concentrations of tumor necrosis factor alpha (TNFα), oxidative stress markers, and antioxidants in patients with endometriosis. Methods: Twenty-three infertile women with Stage III or IV endometriosis were recruited for this study. Eleven patients received three courses of GnRHa (1.8 mg s.c. every 28 days), followed by a standard controlled ovarian hyperstimulation (COH) for IVF-ET (ultralong group). The other 12 patients received a standard COH with mid-luteal phase GnRHa down-regulation (control group). The numbers of matured follicles and retrieved oocytes, fertilization rates, implantation rates, clinical pregnancy rate, and intrafollicular concentrations of TNFα, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL) as oxidative stress markers, and melatonin and Cu,Zu-superoxide dismutase (Cu,Zn-SOD) as antioxidants were compared between the two groups.

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Section: Discussionmentioning

confidence: 99%

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Tamura

Takasaki

Nakamura

et al. 2014

Journal of Ovarian Research

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“…Melatonin (N-acetyl-5-methoxytryptamine), the principal secretory product of the pineal gland, produced during the dark phase of the circadian cycle, is a highly conserved antioxidant molecule [24,25] . Melatonin along with its metabolites has been shown to scavenge reactive oxygen species (ROS) or reactive nitrogen species (RNS) [26] .…”

Section: Introductionmentioning

confidence: 99%

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen

Ambali

Ayo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…Such effects allow melatonin to have clinical efficacy across a wide diversity of medical conditions, including neurodegenerative and psychiatric disorders (34) as well as in the management of cancers (35).…”

Section: Melatonergic Pathwaysmentioning

confidence: 99%

Breastfeeding and the gut-brain axis: is there a role for melatonin?

Anderson¹,

Vaillancourt²,

Maes

et al. 2017

Biomolecular Concepts

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The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a significant improvement in the contents of formula feed. In this article, the overlooked role of melatonin and the melatonergic pathways in breast milk and in the regulation of wider breast milk components are reviewed. There is a growing appreciation that the benefits of breastfeeding are mediated by its effects in the infant gut, with consequences for the development of the gut-brain axis and the immune system. The melatonergic pathways are intimately associated with highly researched processes in the gut, gut microbiome and gut-brain axis. As the melatonergic pathways are dependent on the levels of serotonin availability as a necessary precursor, decreased melatonin is linked to depression and depression-associated disorders. The association of breastfeeding and the gut-brain axis with a host of medical conditions may be mediated by their regulation of processes that modulate depression susceptibility. The biological underpinnings of depression include increased levels of pro-inflammatory cytokines, oxidative stress, kynurenine pathway activity and dysregulation of the hypothalamic-pituitary adrenal axis, all of which can decrease melatonergic pathway activity. The inclusion of the melatonergic pathways in the biological interactions of breast milk and gut development has significant theoretical and treatment implications, as well as being important to the prevention of a host of infant-, child-and adult-onset medical conditions.

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Melatonin: A Multitasking Molecule

Cited by 557 publications

References 151 publications

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Breastfeeding and the gut-brain axis: is there a role for melatonin?

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